Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 945644..946299 Replicon chromosome
Accession NZ_AP019853
Organism Neisseria gonorrhoeae strain SS3160

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag FYK59_RS04820 Protein ID WP_003691083.1
Coordinates 945644..946063 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag FYK59_RS04825 Protein ID WP_003688410.1
Coordinates 946063..946299 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYK59_RS04800 940878..942419 - 1542 WP_003701286.1 multidrug efflux MFS transporter -
FYK59_RS04805 942567..943346 + 780 WP_003688416.1 (Fe-S)-binding protein -
FYK59_RS04810 943343..944044 + 702 WP_003688414.1 lactate utilization protein C -
FYK59_RS04815 944041..945495 + 1455 WP_003688412.1 iron-sulfur cluster-binding protein -
FYK59_RS04820 945644..946063 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
FYK59_RS04825 946063..946299 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
FYK59_RS04830 946505..946702 - 198 WP_033910354.1 IS3 family transposase -
FYK59_RS04835 946747..947325 - 579 WP_003688041.1 IS3 family transposase -
FYK59_RS04840 947330..947758 - 429 WP_010360042.1 helix-turn-helix domain-containing protein -
FYK59_RS04845 947970..948356 + 387 Protein_952 IS110 family transposase -
FYK59_RS04850 948739..949629 - 891 WP_003693285.1 succinate--CoA ligase subunit alpha -
FYK59_RS04855 949640..950806 - 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
FYK59_RS04860 950878..951165 - 288 WP_025455945.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T33185 WP_003691083.1 NZ_AP019853:c946063-945644 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

>T33185 NZ_AP019853:c946063-945644 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT33185 WP_003688410.1 NZ_AP019853:c946299-946063 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp

>AT33185 NZ_AP019853:c946299-946063 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References