Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 760170..761737 Replicon chromosome
Accession NZ_AP019850
Organism Vibrio alfacsensis strain 04Ya249

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5706_RS17770 Protein ID WP_221073106.1
Coordinates 760430..761737 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5706_RS17765 Protein ID WP_256997340.1
Coordinates 760170..760430 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5706_RS17735 (VA249_33920) 755501..756364 + 864 WP_221073102.1 endonuclease/exonuclease/phosphatase family protein -
K5706_RS17740 756378..756802 - 425 Protein_636 YeeE/YedE family protein -
K5706_RS17745 (VA249_33950) 756802..757203 - 402 WP_221072113.1 YeeE/YedE thiosulfate transporter family protein -
K5706_RS17750 (VA249_33960) 757230..757523 - 294 WP_211917202.1 metalloregulator ArsR/SmtB family transcription factor -
K5706_RS17755 (VA249_33970) 757672..757818 + 147 WP_221073103.1 pyridine nucleotide-disulfide oxidoreductase -
K5706_RS17760 (VA249_33980) 757986..759689 + 1704 WP_221073104.1 FAD-dependent oxidoreductase -
K5706_RS17765 (VA249_33990) 760170..760430 + 261 WP_256997340.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K5706_RS17770 (VA249_34000) 760430..761737 + 1308 WP_221073106.1 type II toxin-antitoxin system HipA family toxin Toxin
K5706_RS17775 (VA249_34010) 761835..764099 - 2265 WP_221073107.1 hypothetical protein -
K5706_RS17780 (VA249_34020) 764372..764629 - 258 WP_221073108.1 hypothetical protein -
K5706_RS17785 (VA249_34030) 764646..764927 - 282 WP_221073109.1 hypothetical protein -
K5706_RS17790 (VA249_34040) 765264..765656 + 393 WP_221073110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-71)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48853.99 Da        Isoelectric Point: 6.8655

>T33184 WP_221073106.1 NZ_AP019850:760430-761737 [Vibrio alfacsensis]
MASLSAYMNGEKVGTLVKLSNGAHQFQYARTWVESPIGRPLSLSLPLQYQTIKSDCVINYFDNLLPDLIEVRDRIAARYQ
TKSRQTFDLLAIIGKENVGALSFHAEDEIQATTKQLSYETLSAERLKQVLCAHHSKIPLGMIKNDFRISIPGAQEKTALL
KVENDWCIPVNSTPTTHIIKLPIGKIHQPNSVLDMSDSVENEYLCLSLAKCLGFNVPSAEIIYCDDVKAIAIERFDREWS
DDKSWILRRHQEDMCQAFGLPSSLKYEADGGIGIKTIMDLLASSSDSLKDRESFMRFQVFQWLIGATDGHAKNFSININS
DGNYQLTPFYDVLSAFPMLGGNGLNIRSLKLAMGLKATRGRKYHIDKIYSRHFLDTAKECGFDPDAMETILQDFIRAIPH
AIDSVSKSLPYGFPSYVSDSIFENTLKMNKKLTLG

Download         Length: 1308 bp

>T33184 NZ_AP019850:760430-761737 [Vibrio alfacsensis]
ATGGCTTCACTTTCCGCTTACATGAACGGAGAAAAAGTGGGCACGTTAGTCAAACTTTCGAATGGTGCTCACCAGTTCCA
ATATGCTCGCACTTGGGTAGAAAGCCCAATTGGTAGACCATTATCATTGTCTTTACCATTGCAGTATCAAACGATAAAAA
GTGATTGTGTAATTAACTATTTTGATAATTTACTACCCGATCTAATTGAGGTGCGCGACCGAATTGCAGCAAGATACCAA
ACCAAATCTCGTCAAACATTCGATTTACTTGCGATAATTGGCAAAGAAAATGTTGGTGCGTTATCGTTTCATGCAGAAGA
TGAGATTCAGGCGACCACTAAGCAGCTCTCATACGAAACACTATCAGCGGAACGCTTGAAGCAAGTTCTTTGTGCGCACC
ATTCAAAGATCCCCTTAGGAATGATTAAAAACGACTTTCGTATTTCTATTCCTGGTGCTCAAGAAAAAACAGCTCTTTTA
AAGGTCGAGAATGATTGGTGTATCCCCGTAAATTCAACGCCTACCACACACATAATCAAGCTACCCATCGGAAAAATACA
TCAGCCAAACTCAGTGTTGGATATGAGTGACAGCGTAGAAAATGAATATCTGTGCTTAAGTCTAGCTAAATGCTTAGGCT
TCAATGTTCCAAGCGCTGAGATTATTTATTGTGATGACGTAAAAGCTATCGCCATAGAACGGTTCGATAGAGAGTGGTCA
GATGATAAAAGTTGGATTTTACGGCGACATCAAGAAGATATGTGTCAGGCGTTCGGATTACCGTCCTCACTCAAATACGA
GGCTGACGGTGGCATTGGTATAAAAACAATAATGGATCTACTTGCAAGTTCAAGTGACTCATTGAAAGATCGCGAGTCTT
TCATGCGCTTTCAAGTCTTTCAGTGGCTTATCGGTGCTACTGATGGTCATGCAAAAAACTTCTCGATTAACATTAATTCA
GATGGTAATTATCAACTCACACCATTTTATGATGTTCTTTCTGCGTTCCCAATGCTCGGTGGTAATGGATTAAATATACG
GTCGTTAAAACTCGCGATGGGTTTAAAAGCAACGCGAGGTAGAAAATATCATATTGATAAGATCTACTCTCGGCACTTCC
TTGATACGGCAAAAGAATGTGGATTTGATCCAGATGCGATGGAGACTATATTGCAAGATTTCATCCGAGCAATACCACAT
GCTATTGATTCTGTATCAAAATCACTGCCCTATGGTTTTCCTTCCTATGTCAGTGACTCGATCTTTGAAAACACTTTAAA
GATGAATAAAAAACTAACACTTGGTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9752.05 Da        Isoelectric Point: 6.4583

>AT33184 WP_256997340.1 NZ_AP019850:760170-760430 [Vibrio alfacsensis]
MESSMIYNPAQLANQLKLIRTRDSITQAELAKRVGIKQSTLSNFENHPDTTQLKTVFKILQALELGITIQEQNSGINSQH
NIDEVW

Download         Length: 261 bp

>AT33184 NZ_AP019850:760170-760430 [Vibrio alfacsensis]
TTGGAGTCATCTATGATTTACAATCCTGCACAACTCGCAAATCAGTTAAAGCTCATTAGAACAAGAGACAGCATCACTCA
AGCTGAACTGGCTAAACGAGTCGGTATAAAGCAATCAACACTATCGAACTTTGAAAATCATCCAGATACAACGCAACTTA
AAACTGTGTTTAAAATTCTTCAAGCATTAGAGCTGGGGATCACGATCCAAGAACAAAACTCTGGCATAAACTCACAACAC
AACATTGACGAGGTGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References