Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1836932..1837497 Replicon chromosome
Accession NZ_AP019849
Organism Vibrio alfacsensis strain 04Ya249

Toxin (Protein)


Gene name relE Uniprot ID A0A916ASF8
Locus tag K5706_RS08215 Protein ID WP_005445239.1
Coordinates 1836932..1837219 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K5706_RS08220 Protein ID WP_165401670.1
Coordinates 1837216..1837497 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5706_RS08155 1832241..1832351 - 111 WP_221071759.1 DUF3265 domain-containing protein -
K5706_RS08160 (VA249_15450) 1832348..1832662 - 315 WP_221069481.1 DNA-binding transcriptional regulator -
K5706_RS08165 (VA249_15460) 1832649..1832981 - 333 WP_012600340.1 type II toxin-antitoxin system RelE/ParE family toxin -
K5706_RS08170 1833084..1833173 - 90 WP_072615218.1 DUF3265 domain-containing protein -
K5706_RS08175 (VA249_15470) 1833287..1833529 + 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K5706_RS08180 (VA249_15480) 1833537..1833836 + 300 WP_221069483.1 type II toxin-antitoxin system RelE/ParE family toxin -
K5706_RS08185 (VA249_15490) 1834022..1834837 - 816 WP_050932680.1 DUF2971 domain-containing protein -
K5706_RS08190 (VA249_15500) 1835085..1835537 + 453 WP_221069484.1 GNAT family N-acetyltransferase -
K5706_RS08195 1835582..1835671 - 90 WP_073514058.1 DUF3265 domain-containing protein -
K5706_RS08200 1835800..1836102 + 303 WP_045396914.1 hypothetical protein -
K5706_RS08205 1836202..1836291 - 90 WP_072829120.1 DUF3265 domain-containing protein -
K5706_RS08215 (VA249_15510) 1836932..1837219 - 288 WP_005445239.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5706_RS08220 (VA249_15520) 1837216..1837497 - 282 WP_165401670.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5706_RS08225 1837588..1837680 - 93 WP_080640453.1 DUF3265 domain-containing protein -
K5706_RS08230 (VA249_15530) 1837786..1838142 + 357 WP_221069485.1 hypothetical protein -
K5706_RS08235 (VA249_15540) 1838297..1839070 - 774 WP_221069486.1 aminoglycoside phosphotransferase family protein -
K5706_RS08240 1839098..1839190 - 93 WP_199455699.1 DUF3265 domain-containing protein -
K5706_RS08245 (VA249_15550) 1839305..1840066 + 762 WP_221069479.1 IS5 family transposase -
K5706_RS08250 1840407..1840499 - 93 WP_005448238.1 DUF3265 domain-containing protein -
K5706_RS08255 (VA249_15570) 1840514..1841299 - 786 WP_009697310.1 NYN domain-containing protein -
K5706_RS23825 1841401..1841463 - 63 Protein_1555 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1839305..1840066 761
- inside Integron - - 1817009..1865094 48085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11031.70 Da        Isoelectric Point: 5.1098

>T33183 WP_005445239.1 NZ_AP019849:c1837219-1836932 [Vibrio alfacsensis]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Download         Length: 288 bp

>T33183 NZ_AP019849:c1837219-1836932 [Vibrio alfacsensis]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAGGTGGGTAAATGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCATACGAATTATCGTGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10442.92 Da        Isoelectric Point: 5.1651

>AT33183 WP_165401670.1 NZ_AP019849:c1837497-1837216 [Vibrio alfacsensis]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARDQVLGRIKK

Download         Length: 282 bp

>AT33183 NZ_AP019849:c1837497-1837216 [Vibrio alfacsensis]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAATTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGATCAAGTACTTGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References