Detailed information of TA system TA033179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1816283..1816832
• Replicon: chromosome
• Accession: NZ_AP019849
• Organism: Vibrio alfacsensis strain 04Ya249

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: K5706_RS08005
• Protein ID: WP_045369102.1
• Coordinates: 1816533..1816832 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: K5706_RS08000
• Protein ID: WP_221069465.1
• Coordinates: 1816283..1816525 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5706_RS07975 (VA249_15180)	1811733..1813070	-	1338	WP_221069461.1	ATP-binding protein	-
K5706_RS07980 (VA249_15190)	1813074..1814492	-	1419	WP_221069432.1	SLC13 family permease	-
K5706_RS07985 (VA249_15200)	1814808..1815377	-	570	WP_221069463.1	HNH endonuclease signature motif containing protein	-
K5706_RS07990 (VA249_15210)	1815578..1816024	-	447	WP_221069428.1	GNAT family N-acetyltransferase	-
K5706_RS07995	1816083..1816169	-	87	Protein_1501	DUF3265 domain-containing protein	-
K5706_RS08000 (VA249_15220)	1816283..1816525	+	243	WP_221069465.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K5706_RS08005 (VA249_15230)	1816533..1816832	+	300	WP_045369102.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K5706_RS08010	1816896..1816988	-	93	WP_221069466.1	DUF3265 domain-containing protein	-
K5706_RS08015 (VA249_15240)	1817009..1817671	-	663	WP_221069468.1	hypothetical protein	-
K5706_RS08020	1818599..1818691	-	93	WP_072884142.1	DUF3265 domain-containing protein	-
K5706_RS08025 (VA249_15260)	1818810..1819016	-	207	WP_221071812.1	hypothetical protein	-
K5706_RS08030	1819219..1819311	-	93	WP_079855036.1	DUF3265 domain-containing protein	-
K5706_RS08035 (VA249_15270)	1819332..1819865	-	534	WP_221069470.1	transcriptional regulator	-
K5706_RS08040	1819902..1820033	-	132	WP_221071756.1	DUF3265 domain-containing protein	-
K5706_RS08045	1820451..1820593	-	143	Protein_1511	DUF3265 domain-containing protein	-
K5706_RS08050	1821411..1821521	-	111	WP_080767748.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11524.16 Da
• Isoelectric Point: 9.6267

>T33179 WP_045369102.1 NZ_AP019849:1816533-1816832 [Vibrio alfacsensis]
MQKNKYKLSNLAQSHLRKVKNYTVENFSELQWRNYKDTLLSGFQMLADNPGLGRSCHELYPNGFYFPIGKHTAYFTKEDD
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T33179 NZ_AP019849:1816533-1816832 [Vibrio alfacsensis]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCCCACTTGCGCAAAGTCAAAAACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGCAACTATAAAGACACTTTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGGTTTAGGAA
GAAGTTGTCACGAGCTATACCCAAATGGCTTTTATTTCCCGATTGGAAAACACACAGCTTATTTCACCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9017.23 Da
• Isoelectric Point: 5.6926

>AT33179 WP_221069465.1 NZ_AP019849:1816283-1816525 [Vibrio alfacsensis]
MHALTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFINSL

Nucleotide

• Length: 243 bp

>AT33179 NZ_AP019849:1816283-1816525 [Vibrio alfacsensis]
ATGCATGCATTAACAGCCAATGATGCCAAACGAAATTTCGGCGAACTACTTCTAAGCGCACAACGCGAGCCAGTAAAAAT
CAGCAAAAACAGTAAAGATACTGTCGTTGTCATGTCCATTCGTGACTTTGAAGAGCTAGAAGCTATGAAAGTTGAGTACC
TCAAACACTGCTTTAAGTCAGCTAAAGAAGACTTGAACAATGGAAACACTGTTGATGGCGAAAGCTTTATAAATTCGCTG
TAA