Detailed information of TA system TA033178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 1251574..1252093
• Replicon: chromosome
• Accession: NZ_AP019846
• Organism: Leptotrichia hongkongensis strain JMUB5056

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: C7NA91
• Locus tag: FVE75_RS05970
• Protein ID: WP_006804080.1
• Coordinates: 1251574..1251831 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: -
• Locus tag: FVE75_RS05975
• Protein ID: WP_147005665.1
• Coordinates: 1251836..1252093 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE75_RS10935	1247016..1247192	+	177	WP_172618789.1	hypothetical protein	-
FVE75_RS05955	1247502..1247975	+	474	WP_147005662.1	GNAT family N-acetyltransferase	-
FVE75_RS10940	1248146..1248304	+	159	WP_172618747.1	hypothetical protein	-
FVE75_RS05960	1248686..1250038	+	1353	WP_147005663.1	hemolysin family protein	-
FVE75_RS05965	1250088..1251470	+	1383	WP_147005664.1	NCS2 family permease	-
FVE75_RS05970	1251574..1251831	-	258	WP_006804080.1	Txe/YoeB family addiction module toxin	Toxin
FVE75_RS05975	1251836..1252093	-	258	WP_147005665.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FVE75_RS05980	1252238..1254283	-	2046	WP_147005666.1	PBP1A family penicillin-binding protein	-
FVE75_RS05985	1254318..1255415	-	1098	WP_147006454.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
FVE75_RS05990	1255590..1255982	-	393	WP_147005667.1	type II toxin-antitoxin system HicB family antitoxin	-
FVE75_RS05995	1256013..1256204	-	192	WP_147005668.1	type II toxin-antitoxin system HicA family toxin	-
FVE75_RS06000	1256294..1256866	-	573	WP_147005669.1	DUF4291 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-59)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10162.63 Da
• Isoelectric Point: 9.7099

>T33178 WP_006804080.1 NZ_AP019846:c1251831-1251574 [Leptotrichia hongkongensis]
MNINWNSEAWKEYVDWQSKDKKVIKKINEIIKDIQRNGNEGIGKAEALKHELSGYWSRRITDKHRFIYKLTENEVIIIAC
ANHYK

Nucleotide

• Length: 258 bp

>T33178 NZ_AP019846:c1251831-1251574 [Leptotrichia hongkongensis]
ATGAACATAAATTGGAATAGTGAAGCATGGAAGGAATATGTAGATTGGCAATCAAAAGATAAAAAAGTTATAAAAAAGAT
AAATGAAATTATAAAGGATATTCAGAGAAATGGAAATGAAGGAATAGGTAAAGCAGAGGCTTTAAAGCATGAATTAAGTG
GGTATTGGAGTAGAAGAATAACTGATAAGCACAGATTTATTTATAAATTGACTGAAAATGAAGTTATAATAATAGCTTGT
GCTAATCATTACAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10273.56 Da
• Isoelectric Point: 4.7473

>AT33178 WP_147005665.1 NZ_AP019846:c1252093-1251836 [Leptotrichia hongkongensis]
MIATNYSNIRNNFKKYCDKATRDYETIIVTRKNDENVVLMSEEEYNNLIENLYIMSNKDYYNELLKRKDEVEKGKVEKHD
LIEVE

Nucleotide

• Length: 258 bp

>AT33178 NZ_AP019846:c1252093-1251836 [Leptotrichia hongkongensis]
ATGATAGCTACAAATTATTCTAATATTAGAAATAATTTTAAAAAGTATTGTGATAAGGCAACAAGAGATTATGAAACAAT
AATTGTAACTAGAAAAAATGATGAAAATGTGGTATTAATGAGTGAAGAAGAATACAATAATCTTATAGAAAATTTGTATA
TTATGTCTAATAAAGATTATTATAATGAATTGTTGAAAAGAAAAGATGAGGTTGAAAAAGGGAAAGTTGAGAAACATGAT
TTAATTGAGGTGGAATAA

Structures

Toxin

• AlphaFold DB: C7NA91