Detailed information of TA system TA033177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1241491..1242031
• Replicon: chromosome
• Accession: NZ_AP019846
• Organism: Leptotrichia hongkongensis strain JMUB5056

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FVE75_RS05930
• Protein ID: WP_197735179.1
• Coordinates: 1241491..1241763 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A510KLJ5
• Locus tag: FVE75_RS05935
• Protein ID: WP_026746383.1
• Coordinates: 1241756..1242031 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE75_RS05910	1238063..1238836	+	774	WP_147005654.1	type III pantothenate kinase	-
FVE75_RS05915	1238853..1239764	+	912	WP_147005655.1	lipase	-
FVE75_RS05920	1239736..1240548	+	813	WP_147005656.1	phospholipase D family protein	-
FVE75_RS05925	1240600..1240968	-	369	WP_147005657.1	hypothetical protein	-
FVE75_RS05930	1241491..1241763	-	273	WP_197735179.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FVE75_RS05935	1241756..1242031	-	276	WP_026746383.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVE75_RS05940	1242670..1242831	-	162	WP_172618746.1	hypothetical protein	-
FVE75_RS05945	1242992..1244791	-	1800	WP_147005660.1	oligoendopeptidase F	-
FVE75_RS05950	1245211..1246590	+	1380	WP_147005661.1	argininosuccinate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10557.33 Da
• Isoelectric Point: 9.6116

>T33177 WP_197735179.1 NZ_AP019846:c1241763-1241491 [Leptotrichia hongkongensis]
VYKVKFTGQFKKDLKLAKKQGKNLDTLFNVIKVLEKGEKLDDKYRDHSLSGKYKGTRECHIEPDWLLVYEIIDNVLVLVL
YRLGSHSELF

Nucleotide

• Length: 273 bp

>T33177 NZ_AP019846:c1241763-1241491 [Leptotrichia hongkongensis]
GTGTATAAAGTTAAATTTACAGGACAATTTAAAAAAGATTTGAAATTGGCAAAAAAACAAGGAAAAAACCTTGATACATT
ATTTAACGTGATAAAAGTCTTGGAAAAAGGTGAAAAACTTGATGATAAATATAGAGACCATAGTTTATCTGGAAAATATA
AAGGAACAAGAGAATGCCATATTGAGCCTGATTGGTTGTTAGTTTATGAAATAATAGATAATGTGCTGGTACTTGTATTG
TATAGATTAGGTTCACACTCAGAACTGTTTTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10390.89 Da
• Isoelectric Point: 4.7704

>AT33177 WP_026746383.1 NZ_AP019846:c1242031-1241756 [Leptotrichia hongkongensis]
MANANLSIRVDKETKEKANELFNKFGLTMTTAVNMFLKTAIRENRIPFELKLEEEPNEVTMKAIEEGRRIAKDDSVKGYD
SIEELREALGV

Nucleotide

• Length: 276 bp

>AT33177 NZ_AP019846:c1242031-1241756 [Leptotrichia hongkongensis]
ATGGCAAATGCAAATTTAAGTATTAGAGTTGATAAAGAAACAAAAGAAAAAGCGAATGAATTATTTAACAAATTTGGCTT
GACAATGACAACCGCAGTAAATATGTTCTTAAAAACTGCAATTAGGGAAAATAGAATCCCTTTTGAATTGAAATTGGAAG
AAGAGCCAAATGAAGTAACAATGAAAGCAATTGAAGAAGGAAGACGGATTGCAAAAGACGATAGTGTAAAGGGATATGAC
AGTATAGAGGAGTTGAGAGAGGCACTTGGTGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A510KLJ5