Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09907-MazE
Location 2338515..2339089 Replicon chromosome
Accession NZ_AP019845
Organism Leptotrichia trevisanii strain JMUB4039

Toxin (Protein)


Gene name mazF Uniprot ID A0A510K5V8
Locus tag FVE78_RS10310 Protein ID WP_026748727.1
Coordinates 2338515..2338844 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A510L2B8
Locus tag FVE78_RS10315 Protein ID WP_018450842.1
Coordinates 2338838..2339089 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE78_RS10290 2334830..2335414 - 585 WP_026748723.1 biotin transporter BioY -
FVE78_RS10295 2335517..2336686 - 1170 WP_146999190.1 molecular chaperone DnaJ -
FVE78_RS10300 2336851..2337357 - 507 WP_026748725.1 hypothetical protein -
FVE78_RS10305 2337555..2338436 - 882 WP_146999191.1 aldose 1-epimerase family protein -
FVE78_RS10310 2338515..2338844 - 330 WP_026748727.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FVE78_RS10315 2338838..2339089 - 252 WP_018450842.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FVE78_RS10320 2339225..2341051 - 1827 WP_146999192.1 molecular chaperone DnaK -
FVE78_RS10325 2341063..2341674 - 612 WP_146999193.1 hypothetical protein -
FVE78_RS10330 2341680..2342258 - 579 WP_146999194.1 nucleotide exchange factor GrpE -
FVE78_RS10335 2342283..2343293 - 1011 WP_146999195.1 heat-inducible transcriptional repressor HrcA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-100)

Antitoxin

Antitoxin PemI-like

(5-83)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12374.45 Da        Isoelectric Point: 6.2213

>T33175 WP_026748727.1 NZ_AP019845:c2338844-2338515 [Leptotrichia trevisanii]
MVKQGDIIKINFNPQMGHEQAGYRPAVIVSNGTFNRVTNLVLVCPITDSIDKFPLHIKLDNRTATTGIILCEHLKSLDIN
KRSYKIIEKLPEDILEKVVDIIFSEIEIE

Download         Length: 330 bp

>T33175 NZ_AP019845:c2338844-2338515 [Leptotrichia trevisanii]
ATGGTAAAACAAGGGGATATAATAAAGATAAATTTTAATCCGCAGATGGGACATGAACAAGCTGGATATCGTCCTGCGGT
TATAGTAAGTAATGGTACTTTCAATAGGGTAACAAATTTAGTTTTAGTTTGTCCAATTACAGATTCAATAGACAAATTTC
CGCTTCATATAAAATTAGACAATCGGACTGCTACGACGGGCATAATTTTATGTGAACACCTTAAATCTTTGGATATTAAT
AAAAGAAGTTATAAAATTATTGAAAAATTACCAGAGGATATTTTAGAAAAAGTCGTAGACATTATTTTTTCAGAAATAGA
AATTGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9814.46 Da        Isoelectric Point: 7.9594

>AT33175 WP_018450842.1 NZ_AP019845:c2339089-2338838 [Leptotrichia trevisanii]
MAEVLKIQKWGNSQGIRLPKKILEILDLKVNDTILIEEGDNCLKLKKIKKEKRKTIKELFANYNEDYEKQEIDWGEPVGK
EVW

Download         Length: 252 bp

>AT33175 NZ_AP019845:c2339089-2338838 [Leptotrichia trevisanii]
ATGGCAGAGGTTTTAAAAATACAAAAATGGGGAAACAGTCAGGGAATAAGACTTCCTAAAAAAATATTGGAAATACTTGA
TTTAAAAGTAAATGATACTATTTTGATAGAAGAGGGAGATAATTGCCTTAAATTAAAAAAAATAAAAAAAGAAAAAAGAA
AGACAATAAAGGAATTGTTTGCAAATTATAATGAGGATTATGAAAAACAGGAAATAGATTGGGGAGAACCAGTAGGTAAA
GAGGTATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510K5V8

Antitoxin

Source ID Structure
AlphaFold DB A0A510L2B8

References