Detailed information of TA system TA033174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1535971..1536547
• Replicon: chromosome
• Accession: NZ_AP019845
• Organism: Leptotrichia trevisanii strain JMUB4039

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FVE78_RS06985
• Protein ID: WP_146998723.1
• Coordinates: 1535971..1536267 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A510L0E3
• Locus tag: FVE78_RS06990
• Protein ID: WP_026749263.1
• Coordinates: 1536257..1536547 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE78_RS06965	1531966..1532187	-	222	WP_146996967.1	hypothetical protein	-
FVE78_RS06970	1532357..1532614	-	258	WP_146998720.1	hypothetical protein	-
FVE78_RS06975	1532862..1533554	-	693	WP_146998721.1	50S ribosome-binding GTPase	-
FVE78_RS06980	1534885..1535892	-	1008	WP_146998722.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
FVE78_RS06985	1535971..1536267	-	297	WP_146998723.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FVE78_RS06990	1536257..1536547	-	291	WP_026749263.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVE78_RS06995	1536623..1537566	-	944	Protein_1404	Abi family protein	-
FVE78_RS07000	1537896..1539878	-	1983	WP_146998724.1	hypothetical protein	-
FVE78_RS07005	1539917..1540483	-	567	WP_146998725.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1534885..1544158	9273

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (11-98)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-72)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11329.47 Da
• Isoelectric Point: 10.0837

>T33174 WP_146998723.1 NZ_AP019845:c1536267-1535971 [Leptotrichia trevisanii]
MKGKKEEYKYSVILTGKFKKHLKNLKKQKKDLKLLESIISILAKGEKLPPKNKDHKLVNNYDGARECHITPDWLLIYEIV
EDKLILILLASGSHGELF

Nucleotide

• Length: 297 bp

>T33174 NZ_AP019845:c1536267-1535971 [Leptotrichia trevisanii]
ATGAAGGGTAAAAAAGAAGAGTATAAATATTCTGTTATTCTTACTGGGAAATTTAAAAAACATTTAAAAAATCTAAAAAA
ACAGAAAAAAGATTTAAAATTATTGGAAAGTATAATCTCAATATTAGCAAAAGGAGAAAAACTTCCTCCTAAAAACAAGG
ATCATAAATTAGTCAATAATTATGATGGGGCAAGAGAATGTCATATAACTCCAGATTGGTTATTAATCTACGAGATAGTT
GAAGATAAATTAATATTGATTTTATTAGCATCAGGTAGTCATGGTGAACTATTCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10909.37 Da
• Isoelectric Point: 4.7049

>AT33174 WP_026749263.1 NZ_AP019845:c1536547-1536257 [Leptotrichia trevisanii]
MATVNTSIKIDEETKKEAQKLFKDLGLSLSTAINIFLKQAIREKGIPFYINSLPENSELAQAFEEVKQIKKNPSNYKSYS
SPEEMFKDVLGEDYEG

Nucleotide

• Length: 291 bp

>AT33174 NZ_AP019845:c1536547-1536257 [Leptotrichia trevisanii]
ATGGCAACAGTTAATACAAGTATAAAGATAGATGAGGAAACTAAAAAAGAAGCACAGAAATTATTTAAAGATTTAGGATT
AAGCCTTAGTACAGCAATTAATATATTTTTAAAACAAGCTATAAGAGAAAAAGGCATACCATTTTATATAAATTCTTTAC
CTGAAAATTCAGAATTGGCTCAAGCATTTGAAGAAGTTAAACAAATTAAGAAAAATCCTTCAAATTATAAATCCTACAGT
AGTCCAGAAGAAATGTTTAAAGATGTCTTGGGAGAAGATTATGAAGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A510L0E3