Detailed information of TA system TA033173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/Txe-RelB
• Location: 1268745..1269261
• Replicon: chromosome
• Accession: NZ_AP019845
• Organism: Leptotrichia trevisanii strain JMUB4039

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FVE78_RS05750
• Protein ID: WP_146998557.1
• Coordinates: 1269004..1269261 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: A0A510KLT6
• Locus tag: FVE78_RS05745
• Protein ID: WP_026749002.1
• Coordinates: 1268745..1269002 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE78_RS05745	1268745..1269002	+	258	WP_026749002.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FVE78_RS05750	1269004..1269261	+	258	WP_146998557.1	Txe/YoeB family addiction module toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-59)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10375.91 Da
• Isoelectric Point: 10.1995

>T33173 WP_146998557.1 NZ_AP019845:1269004-1269261 [Leptotrichia trevisanii]
MNINWNNKAWKEYVEWQSKDKKIVKKINEIIKDIQRNGNEGLNKFETLRHGLSGYWSRRITDRHRFIYKLTENEIVIIAC
ANYYK

Nucleotide

• Length: 258 bp

>T33173 NZ_AP019845:1269004-1269261 [Leptotrichia trevisanii]
ATGAATATAAATTGGAATAACAAAGCATGGAAAGAATACGTAGAATGGCAATCGAAAGATAAAAAAATTGTTAAGAAGAT
TAATGAAATTATTAAAGATATTCAGAGAAATGGGAATGAGGGGTTAAATAAATTTGAGACTTTAAGACATGGGTTAAGTG
GTTACTGGAGCAGAAGGATAACTGACAGGCATAGATTTATTTATAAATTGACTGAAAATGAGATTGTGATAATTGCTTGT
GCCAATTATTATAAATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10179.55 Da
• Isoelectric Point: 4.9166

>AT33173 WP_026749002.1 NZ_AP019845:1268745-1269002 [Leptotrichia trevisanii]
MIATNYSNIRNNLKKYCDKATRDSETIIITRKNDENVVLMSIDEYNNLMENLYIMSNKDYYNELLKRKEEVEKGKVEKHD
LIEVE

Nucleotide

• Length: 258 bp

>AT33173 NZ_AP019845:1268745-1269002 [Leptotrichia trevisanii]
ATGATAGCTACAAATTATTCTAATATTAGAAATAATCTAAAAAAATATTGTGACAAGGCAACACGAGATTCTGAAACAAT
AATTATAACTAGAAAAAATGATGAAAATGTTGTGTTGATGAGTATAGACGAATACAATAACTTGATGGAAAATTTGTATA
TTATGTCTAATAAGGATTATTATAATGAATTACTTAAAAGAAAGGAAGAAGTTGAAAAAGGGAAAGTTGAAAAACATGAT
TTAATTGAGGTGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A510KLT6