Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 757492..758011 Replicon chromosome
Accession NZ_AP019845
Organism Leptotrichia trevisanii strain JMUB4039

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FVE78_RS03485 Protein ID WP_146998277.1
Coordinates 757739..758011 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FVE78_RS03480 Protein ID WP_146998276.1
Coordinates 757492..757746 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE78_RS03445 752698..753237 + 540 WP_146998269.1 hypothetical protein -
FVE78_RS03450 753272..754087 + 816 WP_146998270.1 DUF2262 domain-containing protein -
FVE78_RS03455 754154..754528 + 375 WP_146998271.1 hypothetical protein -
FVE78_RS03460 754968..755438 + 471 WP_146998272.1 hypothetical protein -
FVE78_RS03465 755461..756516 + 1056 WP_146998273.1 prolyl oligopeptidase family serine peptidase -
FVE78_RS03470 756630..756887 + 258 WP_146998274.1 endonuclease -
FVE78_RS03475 756929..757387 + 459 WP_146998275.1 hypothetical protein -
FVE78_RS03480 757492..757746 + 255 WP_146998276.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FVE78_RS03485 757739..758011 + 273 WP_146998277.1 type II toxin-antitoxin system YafQ family toxin Toxin
FVE78_RS03490 758061..759119 + 1059 WP_146998278.1 3-isopropylmalate dehydrogenase -
FVE78_RS03495 759164..759826 + 663 WP_146996238.1 hypothetical protein -
FVE78_RS03500 759854..760639 + 786 WP_146998279.1 ATP-binding cassette domain-containing protein -
FVE78_RS03505 760677..761732 + 1056 WP_146998280.1 DMT family transporter -
FVE78_RS03510 761899..762555 + 657 WP_146998281.1 DNA alkylation repair protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-82)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10954.95 Da        Isoelectric Point: 9.7919

>T33172 WP_146998277.1 NZ_AP019845:757739-758011 [Leptotrichia trevisanii]
MLKIRYQVKFKKDYKRVIKRGCNKKLFEEVLFYLVNEKPLPEKYRDHCLTGDYKGFRECHIQPDWLLIYKIEKDILVLTL
SRTGTHSDLF

Download         Length: 273 bp

>T33172 NZ_AP019845:757739-758011 [Leptotrichia trevisanii]
ATGCTTAAAATCAGGTATCAGGTTAAATTTAAGAAAGATTATAAAAGGGTAATAAAAAGAGGATGCAACAAAAAATTATT
TGAAGAAGTTCTTTTTTATTTAGTAAATGAAAAGCCTTTGCCTGAAAAATATAGAGATCATTGTCTTACTGGCGATTACA
AAGGATTTAGAGAATGTCATATTCAGCCTGATTGGTTGTTAATTTATAAAATTGAAAAAGATATTTTGGTTTTAACGTTG
TCAAGGACAGGAACACATTCTGATTTATTTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9492.08 Da        Isoelectric Point: 4.8659

>AT33172 WP_146998276.1 NZ_AP019845:757492-757746 [Leptotrichia trevisanii]
MATVTARVDENVKKEAETLFKKMGLNMSTAMNLFLKKCILEQGIPFELKVPNRETRKVLDEVEKGVGLSKTFDSIDELME
DLNA

Download         Length: 255 bp

>AT33172 NZ_AP019845:757492-757746 [Leptotrichia trevisanii]
ATGGCTACAGTAACAGCTAGAGTTGATGAAAATGTGAAAAAAGAAGCGGAAACTTTATTTAAAAAAATGGGGCTTAATAT
GAGTACTGCTATGAATTTATTTTTGAAGAAGTGTATTTTGGAGCAGGGGATTCCTTTTGAATTGAAAGTGCCGAATAGAG
AAACTAGAAAGGTTTTGGATGAAGTTGAAAAAGGTGTTGGATTAAGCAAAACTTTTGATAGCATAGATGAATTGATGGAG
GATTTGAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References