Detailed information of TA system TA033170

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 943411..943951
• Replicon: chromosome
• Accession: NZ_AP019841
• Organism: Leptotrichia wadei strain JMUB3936

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FVE74_RS04525
• Protein ID: WP_197735163.1
• Coordinates: 943679..943951 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FVE74_RS04520
• Protein ID: WP_147003420.1
• Coordinates: 943411..943686 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE74_RS04510	939565..941265	+	1701	WP_147003418.1	AAA family ATPase	-
FVE74_RS04515	941475..943304	+	1830	WP_147003419.1	oligoendopeptidase F	-
FVE74_RS04520	943411..943686	+	276	WP_147003420.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVE74_RS04525	943679..943951	+	273	WP_197735163.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FVE74_RS04530	943994..944695	+	702	WP_147003422.1	hypothetical protein	-
FVE74_RS04535	944720..945451	+	732	WP_147003423.1	OmpA family protein	-
FVE74_RS04540	945604..946800	-	1197	WP_147003424.1	sel1 repeat family protein	-
FVE74_RS04545	947024..947368	-	345	WP_147003425.1	hypothetical protein	-
FVE74_RS04550	947555..948388	-	834	WP_147003426.1	phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10791.80 Da
• Isoelectric Point: 10.1402

>T33170 WP_197735163.1 NZ_AP019841:943679-943951 [Leptotrichia wadei]
VYKIKFTRQFKKELKLAKKQGKNINKLFKIVDILAEKKVLDIKYKDHALISNYKGFRECHIEPDWLLIYKYYDDILVLSL
SRLGSHSELF

Nucleotide

• Length: 273 bp

>T33170 NZ_AP019841:943679-943951 [Leptotrichia wadei]
GTGTATAAAATTAAATTTACAAGACAATTCAAGAAAGAATTGAAATTAGCCAAAAAGCAAGGAAAAAATATTAATAAATT
ATTTAAAATCGTTGATATTTTAGCTGAAAAGAAAGTATTAGACATTAAATATAAAGATCATGCATTAATCAGTAATTACA
AAGGATTTAGAGAATGCCATATTGAACCTGATTGGTTATTAATATATAAATATTATGATGATATTTTAGTCTTATCATTA
TCTCGTTTAGGTTCACACTCAGAACTGTTTTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10449.87 Da
• Isoelectric Point: 4.5117

>AT33170 WP_147003420.1 NZ_AP019841:943411-943686 [Leptotrichia wadei]
MANTNLSIRVDKETKEKANELFNKFGLTMTTAVNMFLKTAIRENRIPFELKLEEEPNEVTLEAMREADRIARDDSVKGYD
SIEELREALGV

Nucleotide

• Length: 276 bp

>AT33170 NZ_AP019841:943411-943686 [Leptotrichia wadei]
ATGGCAAATACAAATTTAAGTATTAGAGTTGATAAAGAAACAAAAGAAAAAGCGAACGAATTATTTAACAAATTTGGCTT
GACAATGACAACTGCAGTAAATATGTTCTTAAAAACTGCAATTAGAGAAAATAGAATTCCTTTTGAATTGAAATTGGAAG
AAGAGCCAAATGAAGTGACTTTAGAAGCAATGAGAGAAGCTGATAGAATTGCAAGAGATGACAGTGTAAAGGGATATGAC
AGCATAGAGGAGTTGAGAGAGGCACTTGGTGTATAA