Detailed information of TA system TA033169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1688972..1689545
• Replicon: chromosome
• Accession: NZ_AP019840
• Organism: Leptotrichia trevisanii strain JMUB3935

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FVE79_RS07905
• Protein ID: WP_146996971.1
• Coordinates: 1688972..1689265 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A510L0E3
• Locus tag: FVE79_RS07910
• Protein ID: WP_026749263.1
• Coordinates: 1689255..1689545 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE79_RS07880	1684469..1685161	-	693	WP_026749259.1	50S ribosome-binding GTPase	-
FVE79_RS07885	1685318..1685614	-	297	WP_036095739.1	4Fe-4S cluster-binding domain-containing protein	-
FVE79_RS07890	1685616..1686267	-	652	Protein_1573	50S ribosome-binding GTPase	-
FVE79_RS07895	1686471..1686653	-	183	WP_146996969.1	hypothetical protein	-
FVE79_RS07900	1687886..1688893	-	1008	WP_146996970.1	class 1b ribonucleoside-diphosphate reductase subunit beta	-
FVE79_RS07905	1688972..1689265	-	294	WP_146996971.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FVE79_RS07910	1689255..1689545	-	291	WP_026749263.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVE79_RS07915	1689621..1690565	-	945	WP_146996972.1	Abi family protein	-
FVE79_RS07920	1690741..1691748	-	1008	WP_146996973.1	hypothetical protein	-
FVE79_RS07925	1691790..1692422	-	633	WP_146996974.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (10-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-72)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11243.42 Da
• Isoelectric Point: 10.2580

>T33169 WP_146996971.1 NZ_AP019840:c1689265-1688972 [Leptotrichia trevisanii]
MKGKKEEKYSIILTGKFKKHLKNLKKQKKDLKLLESIISILAKGEKLPPKNKDHKLVNNYDGARECRITPDWLLIYEIIE
DKLILILLASGSHSELF

Nucleotide

• Length: 294 bp

>T33169 NZ_AP019840:c1689265-1688972 [Leptotrichia trevisanii]
ATGAAGGGTAAAAAAGAAGAGAAATATTCTATTATTCTTACTGGGAAATTTAAAAAACATTTAAAAAATCTAAAAAAACA
GAAAAAAGATTTAAAATTATTGGAAAGTATAATCTCAATATTAGCAAAAGGAGAAAAACTTCCTCCTAAAAACAAGGATC
ATAAATTAGTTAATAATTATGATGGGGCAAGAGAATGTCGTATAACTCCAGATTGGTTATTAATCTATGAGATAATTGAA
GATAAATTAATATTGATTTTATTAGCATCAGGTAGTCATAGTGAACTATTCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10909.37 Da
• Isoelectric Point: 4.7049

>AT33169 WP_026749263.1 NZ_AP019840:c1689545-1689255 [Leptotrichia trevisanii]
MATVNTSIKIDEETKKEAQKLFKDLGLSLSTAINIFLKQAIREKGIPFYINSLPENSELAQAFEEVKQIKKNPSNYKSYS
SPEEMFKDVLGEDYEG

Nucleotide

• Length: 291 bp

>AT33169 NZ_AP019840:c1689545-1689255 [Leptotrichia trevisanii]
ATGGCAACAGTTAATACAAGTATAAAGATAGATGAGGAAACTAAAAAAGAAGCACAGAAATTATTTAAAGATTTAGGATT
AAGCCTTAGTACAGCAATTAATATATTTTTAAAACAGGCTATAAGAGAAAAAGGCATACCATTTTATATAAATTCTTTAC
CTGAAAATTCAGAATTGGCTCAAGCATTTGAAGAAGTCAAACAAATTAAGAAAAATCCTTCAAATTATAAATCGTACAGT
AGTCCAGAAGAAATGTTTAAAGATGTCTTGGGAGAAGATTATGAAGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A510L0E3