Detailed information of TA system TA033168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1631160..1631700
• Replicon: chromosome
• Accession: NZ_AP019840
• Organism: Leptotrichia trevisanii strain JMUB3935

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FVE79_RS07615
• Protein ID: WP_197736114.1
• Coordinates: 1631160..1631432 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A510KLJ5
• Locus tag: FVE79_RS07620
• Protein ID: WP_026746383.1
• Coordinates: 1631425..1631700 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE79_RS07590	1626438..1628105	+	1668	WP_146996922.1	OPT/YSL family transporter	-
FVE79_RS07595	1628187..1628960	+	774	WP_146996923.1	type III pantothenate kinase	-
FVE79_RS07600	1628971..1629882	+	912	WP_146996924.1	lipase	-
FVE79_RS07605	1629854..1630666	+	813	WP_146996925.1	phospholipase D family protein	-
FVE79_RS07610	1630718..1631086	-	369	WP_146996926.1	hypothetical protein	-
FVE79_RS07615	1631160..1631432	-	273	WP_197736114.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FVE79_RS07620	1631425..1631700	-	276	WP_026746383.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVE79_RS07625	1632198..1632656	-	459	WP_146996928.1	hypothetical protein	-
FVE79_RS07630	1632697..1634496	-	1800	WP_146996929.1	oligoendopeptidase F	-
FVE79_RS07635	1634616..1634798	-	183	WP_146996930.1	hypothetical protein	-
FVE79_RS07640	1634872..1635768	-	897	WP_146996931.1	RNA-binding protein	-
FVE79_RS07645	1635781..1636188	-	408	WP_146996932.1	DUF1232 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10571.35 Da
• Isoelectric Point: 9.6116

>T33168 WP_197736114.1 NZ_AP019840:c1631432-1631160 [Leptotrichia trevisanii]
VYKVKFTGQFKKDLKLAKKQGKNLDTLFNVIKILEKGEKLDDKYRDHSLSGKYKGTRECHIEPDWLLVYEIIDNVLVLVL
YRLGSHSELF

Nucleotide

• Length: 273 bp

>T33168 NZ_AP019840:c1631432-1631160 [Leptotrichia trevisanii]
GTGTATAAAGTTAAATTTACAGGACAATTTAAAAAAGATTTGAAATTGGCAAAAAAACAAGGAAAAAACCTTGATACATT
ATTTAACGTGATAAAAATTTTGGAAAAAGGTGAAAAACTTGATGATAAATATAGAGACCATAGTTTATCTGGAAAATATA
AAGGAACAAGAGAATGCCATATTGAGCCTGATTGGTTGTTAGTTTATGAAATAATAGATAATGTGCTGGTACTTGTATTG
TATAGATTAGGTTCACACTCAGAACTGTTTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10390.89 Da
• Isoelectric Point: 4.7704

>AT33168 WP_026746383.1 NZ_AP019840:c1631700-1631425 [Leptotrichia trevisanii]
MANANLSIRVDKETKEKANELFNKFGLTMTTAVNMFLKTAIRENRIPFELKLEEEPNEVTMKAIEEGRRIAKDDSVKGYD
SIEELREALGV

Nucleotide

• Length: 276 bp

>AT33168 NZ_AP019840:c1631700-1631425 [Leptotrichia trevisanii]
ATGGCAAATGCAAATTTAAGTATTAGAGTTGATAAAGAAACAAAAGAAAAAGCGAATGAATTATTTAACAAATTTGGATT
GACAATGACAACAGCAGTAAATATGTTCTTAAAAACTGCAATTAGAGAAAATAGAATCCCTTTTGAATTGAAATTGGAAG
AAGAGCCAAATGAAGTGACAATGAAAGCAATTGAAGAAGGAAGACGGATAGCAAAAGATGATAGTGTAAAGGGATATGAC
AGCATAGAGGAGTTGAGAGAGGCACTTGGTGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A510KLJ5