Detailed information of TA system TA033166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 828852..829371
• Replicon: chromosome
• Accession: NZ_AP019840
• Organism: Leptotrichia trevisanii strain JMUB3935

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C7NBQ0
• Locus tag: FVE79_RS03860
• Protein ID: WP_015769920.1
• Coordinates: 829099..829371 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FVE79_RS03855
• Protein ID: WP_146996236.1
• Coordinates: 828852..829106 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE79_RS03820	824104..824643	+	540	WP_146996229.1	hypothetical protein	-
FVE79_RS03825	824678..825493	+	816	WP_146996230.1	DUF2262 domain-containing protein	-
FVE79_RS03830	825560..825934	+	375	WP_146996231.1	hypothetical protein	-
FVE79_RS03835	826320..826790	+	471	WP_146996232.1	hypothetical protein	-
FVE79_RS03840	826813..827868	+	1056	WP_146996233.1	prolyl oligopeptidase family serine peptidase	-
FVE79_RS13460	828117..828275	+	159	WP_172619069.1	hypothetical protein	-
FVE79_RS03850	828289..828747	+	459	WP_146996235.1	hypothetical protein	-
FVE79_RS03855	828852..829106	+	255	WP_146996236.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVE79_RS03860	829099..829371	+	273	WP_015769920.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
FVE79_RS03865	829421..830479	+	1059	WP_146996237.1	3-isopropylmalate dehydrogenase	-
FVE79_RS03870	830524..831186	+	663	WP_146996238.1	hypothetical protein	-
FVE79_RS03875	831214..831999	+	786	WP_146996239.1	ATP-binding cassette domain-containing protein	-
FVE79_RS03880	832037..833094	+	1058	Protein_755	EamA family transporter	-
FVE79_RS03885	833262..833918	+	657	WP_146996240.1	DNA alkylation repair protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10986.93 Da
• Isoelectric Point: 9.8863

>T33166 WP_015769920.1 NZ_AP019840:829099-829371 [Leptotrichia trevisanii]
MLKIRYQVKFKKDYKRAIKRGCNKKLFEEVLFYLVNEKPLPEKYRDHYLTGDYKGFRECHIQPDWLLIYKIEKDILVLTL
SRTGTHSDLF

Nucleotide

• Length: 273 bp

>T33166 NZ_AP019840:829099-829371 [Leptotrichia trevisanii]
ATGCTTAAAATCAGATACCAGGTTAAATTCAAGAAAGATTATAAAAGGGCAATAAAAAGAGGGTGTAACAAAAAATTATT
TGAAGAAGTCCTTTTTTATTTGGTAAATGAGAAACCTTTGCCTGAAAAATATAGAGATCATTATCTTACTGGCGATTATA
AAGGATTTAGAGAATGTCATATTCAGCCTGATTGGTTGTTAATTTATAAAATTGAAAAAGATATTTTGGTTTTAACGTTG
TCAAGGACAGGAACACATTCTGATTTATTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9419.96 Da
• Isoelectric Point: 4.4012

>AT33166 WP_146996236.1 NZ_AP019840:828852-829106 [Leptotrichia trevisanii]
MATVTARVDENVKKEAETLFKKMGLNMSTAMNLFLKKCILEQGIPFELKVPNGETRKVLDEVEKGIGLSEIFDSIDELME
DLNA

Nucleotide

• Length: 255 bp

>AT33166 NZ_AP019840:828852-829106 [Leptotrichia trevisanii]
ATGGCTACAGTAACAGCTAGAGTTGATGAAAATGTCAAAAAAGAAGCGGAAACATTATTTAAAAAAATGGGGCTTAATAT
GAGTACTGCTATGAATTTATTTTTGAAGAAATGTATTTTGGAGCAGGGGATTCCGTTTGAGTTGAAAGTTCCAAATGGAG
AAACCAGAAAGGTTTTGGATGAAGTTGAAAAAGGTATTGGGTTAAGCGAAATTTTTGATAGCATAGATGAGTTGATGGAG
GATTTGAATGCTTAA

Structures

Toxin

• AlphaFold DB: A0A510KJI4