Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 8299..8771 Replicon plasmid pJMUB3934p2
Accession NZ_AP019837
Organism Leptotrichia wadei strain JMUB3934

Toxin (Protein)


Gene name relE Uniprot ID U2RV34
Locus tag FVE76_RS11535 Protein ID WP_021745737.1
Coordinates 8499..8771 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C9N208
Locus tag FVE76_RS11530 Protein ID WP_006806162.1
Coordinates 8299..8514 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE76_RS11510 3490..4335 - 846 WP_060917629.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
FVE76_RS11515 4332..4931 - 600 WP_146965067.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
FVE76_RS11520 5027..6085 - 1059 WP_060917631.1 Abi family protein -
FVE76_RS11525 6427..7044 + 618 WP_146965068.1 recombinase family protein -
FVE76_RS11825 7073..7243 + 171 WP_172617823.1 hypothetical protein -
FVE76_RS11530 8299..8514 + 216 WP_006806162.1 hypothetical protein Antitoxin
FVE76_RS11535 8499..8771 + 273 WP_021745737.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVE76_RS11540 8879..9808 - 930 WP_021745738.1 replication initiation protein -
FVE76_RS11545 10273..11073 - 801 WP_021745739.1 hypothetical protein -
FVE76_RS11550 11082..12782 - 1701 WP_146965072.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..27786 27786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10691.54 Da        Isoelectric Point: 10.6516

>T33165 WP_021745737.1 NZ_AP019837:8499-8771 [Leptotrichia wadei]
MGRTVKYKIIPTPHFVKDFSKLDEFVKKRIKIYLENIAEDPRSKGKMLKANRKGQWRYRIGDYRVIVNIQDENLVVLALE
VGHRKNIYNS

Download         Length: 273 bp

>T33165 NZ_AP019837:8499-8771 [Leptotrichia wadei]
ATGGGAAGAACTGTAAAATATAAAATAATCCCAACTCCACATTTCGTAAAAGACTTTAGCAAACTAGATGAATTTGTAAA
AAAAAGAATAAAAATTTATTTAGAAAATATTGCAGAAGATCCACGCAGTAAAGGAAAAATGTTGAAAGCAAATAGAAAAG
GACAATGGAGATACAGAATAGGAGATTACAGAGTTATTGTAAATATTCAAGATGAAAATTTAGTAGTATTAGCGTTAGAA
GTAGGGCATAGAAAAAATATTTATAATAGTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8155.29 Da        Isoelectric Point: 4.2346

>AT33165 WP_006806162.1 NZ_AP019837:8299-8514 [Leptotrichia wadei]
MASISLKVSDMEKKFLQSMAQFEGVTLSELIKSKVFDSLEDEYDAKIADLRLSEYESYLKNGGEVLKWEEL

Download         Length: 216 bp

>AT33165 NZ_AP019837:8299-8514 [Leptotrichia wadei]
ATGGCTTCTATAAGTTTAAAAGTGTCTGATATGGAAAAAAAATTTTTGCAAAGTATGGCACAATTTGAAGGAGTTACATT
GTCAGAGTTAATAAAATCAAAAGTGTTTGACTCACTAGAAGATGAATACGATGCCAAAATAGCAGATTTAAGATTATCAG
AATATGAAAGTTATTTGAAAAATGGAGGAGAAGTTTTAAAATGGGAAGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510KH77

Antitoxin

Source ID Structure
AlphaFold DB A0A510KIG5

References