Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09907-MazE
Location 2477343..2477917 Replicon chromosome
Accession NZ_AP019831
Organism Leptotrichia trevisanii strain JMUB3870

Toxin (Protein)


Gene name mazF Uniprot ID A0A510K5V8
Locus tag JMUB4039_RS11115 Protein ID WP_026748727.1
Coordinates 2477343..2477672 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A510L2B8
Locus tag JMUB4039_RS11120 Protein ID WP_018450842.1
Coordinates 2477666..2477917 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB4039_RS11095 2473659..2474243 - 585 WP_026748723.1 biotin transporter BioY -
JMUB4039_RS11100 2474346..2475515 - 1170 WP_026748724.1 molecular chaperone DnaJ -
JMUB4039_RS11105 2475679..2476185 - 507 WP_026748725.1 hypothetical protein -
JMUB4039_RS11110 2476383..2477264 - 882 WP_026748726.1 aldose 1-epimerase family protein -
JMUB4039_RS11115 2477343..2477672 - 330 WP_026748727.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JMUB4039_RS11120 2477666..2477917 - 252 WP_018450842.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMUB4039_RS11125 2478054..2479877 - 1824 WP_026748728.1 molecular chaperone DnaK -
JMUB4039_RS11130 2479901..2480581 - 681 WP_155283127.1 hypothetical protein -
JMUB4039_RS11135 2480601..2481188 - 588 WP_026748730.1 nucleotide exchange factor GrpE -
JMUB4039_RS11140 2481213..2482223 - 1011 WP_006805786.1 heat-inducible transcriptional repressor HrcA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-100)

Antitoxin

Antitoxin PemI-like

(5-83)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12374.45 Da        Isoelectric Point: 6.2213

>T33162 WP_026748727.1 NZ_AP019831:c2477672-2477343 [Leptotrichia trevisanii]
MVKQGDIIKINFNPQMGHEQAGYRPAVIVSNGTFNRVTNLVLVCPITDSIDKFPLHIKLDNRTATTGIILCEHLKSLDIN
KRSYKIIEKLPEDILEKVVDIIFSEIEIE

Download         Length: 330 bp

>T33162 NZ_AP019831:c2477672-2477343 [Leptotrichia trevisanii]
ATGGTAAAACAAGGGGATATAATAAAGATAAATTTTAATCCGCAGATGGGACATGAACAAGCTGGATATCGTCCTGCGGT
TATAGTAAGTAATGGTACTTTCAATAGGGTAACAAATTTAGTTTTAGTTTGTCCAATTACAGATTCAATAGACAAATTTC
CGCTTCATATAAAATTAGACAATCGGACTGCTACGACGGGCATAATTTTATGTGAACACCTTAAATCTTTGGATATTAAT
AAAAGAAGTTATAAAATTATTGAAAAATTACCAGAGGATATTTTAGAAAAAGTCGTAGACATTATTTTTTCAGAAATAGA
AATTGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9814.46 Da        Isoelectric Point: 7.9594

>AT33162 WP_018450842.1 NZ_AP019831:c2477917-2477666 [Leptotrichia trevisanii]
MAEVLKIQKWGNSQGIRLPKKILEILDLKVNDTILIEEGDNCLKLKKIKKEKRKTIKELFANYNEDYEKQEIDWGEPVGK
EVW

Download         Length: 252 bp

>AT33162 NZ_AP019831:c2477917-2477666 [Leptotrichia trevisanii]
ATGGCAGAGGTTTTAAAAATACAAAAATGGGGAAACAGTCAGGGAATAAGACTTCCTAAAAAAATATTGGAAATACTTGA
TTTAAAAGTAAATGATACTATTTTGATAGAAGAGGGAGATAATTGCCTTAAATTAAAAAAAATAAAAAAAGAAAAAAGAA
AGACAATAAAGGAATTGTTTGCAAATTATAATGAGGATTATGAAAAACAGGAAATAGATTGGGGAGAACCAGTAGGTAAA
GAGGTATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510K5V8

Antitoxin

Source ID Structure
AlphaFold DB A0A510L2B8

References