Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2427551..2428023 Replicon chromosome
Accession NZ_AP019831
Organism Leptotrichia trevisanii strain JMUB3870

Toxin (Protein)


Gene name relE Uniprot ID A0A510K3M1
Locus tag JMUB4039_RS10945 Protein ID WP_026748581.1
Coordinates 2427751..2428023 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A510K8D7
Locus tag JMUB4039_RS10940 Protein ID WP_026748580.1
Coordinates 2427551..2427766 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB4039_RS10920 2423186..2423347 - 162 Protein_2148 transposase -
JMUB4039_RS10925 2423452..2424362 + 911 Protein_2149 IS30 family transposase -
JMUB4039_RS10930 2425320..2425970 + 651 WP_026748579.1 recombinase family protein -
JMUB4039_RS10935 2426233..2426403 + 171 WP_169720572.1 hypothetical protein -
JMUB4039_RS10940 2427551..2427766 + 216 WP_026748580.1 hypothetical protein Antitoxin
JMUB4039_RS10945 2427751..2428023 + 273 WP_026748581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMUB4039_RS10950 2428177..2429082 - 906 WP_155283120.1 replication initiation protein -
JMUB4039_RS10955 2429228..2429977 - 750 WP_036095472.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10702.66 Da        Isoelectric Point: 10.8186

>T33161 WP_026748581.1 NZ_AP019831:2427751-2428023 [Leptotrichia trevisanii]
MGRIVKYKIIPTPHFVKDFSKLDEFVKKRIKIYLENIAKDPRSKGKMLKANRKGQWRYRIGDYRVIVNIQDENLVVLALE
VGHRKNIYNS

Download         Length: 273 bp

>T33161 NZ_AP019831:2427751-2428023 [Leptotrichia trevisanii]
ATGGGAAGAATTGTAAAATATAAAATAATCCCAACTCCACATTTCGTAAAAGATTTTAGCAAACTAGATGAATTTGTAAA
AAAGAGAATAAAAATTTATTTAGAAAATATTGCAAAAGATCCACGCAGTAAAGGAAAAATGTTGAAAGCAAATAGAAAAG
GACAATGGAGATACAGAATAGGAGATTACAGAGTTATTGTAAATATTCAAGATGAAAATTTAGTAGTATTAGCATTAGAA
GTAGGGCATAGAAAAAATATTTATAATAGTTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8182.32 Da        Isoelectric Point: 4.2346

>AT33161 WP_026748580.1 NZ_AP019831:2427551-2427766 [Leptotrichia trevisanii]
MASISLKVSDMEKKFLQSMAQFEGVTLSELIKSKVFDSLEDEYDAKIADLRLSEYENYLKNGGEVLKWEEL

Download         Length: 216 bp

>AT33161 NZ_AP019831:2427551-2427766 [Leptotrichia trevisanii]
ATGGCTTCTATAAGTTTAAAAGTGTCTGATATGGAAAAAAAATTTTTGCAAAGTATGGCACAATTTGAAGGAGTTACATT
GTCAGAGTTAATAAAATCAAAAGTGTTTGACTCACTAGAAGATGAATATGATGCCAAAATAGCAGATTTAAGATTATCAG
AATATGAAAACTATTTGAAAAATGGAGGAGAAGTTTTAAAATGGGAAGAATTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510K3M1

Antitoxin

Source ID Structure
AlphaFold DB A0A510K8D7

References