Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1634708..1635284 Replicon chromosome
Accession NZ_AP019831
Organism Leptotrichia trevisanii strain JMUB3870

Toxin (Protein)


Gene name relE Uniprot ID U2WFD6
Locus tag JMUB4039_RS07610 Protein ID WP_021770172.1
Coordinates 1634708..1635004 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A510L0E3
Locus tag JMUB4039_RS07615 Protein ID WP_026749263.1
Coordinates 1634994..1635284 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMUB4039_RS07580 1629943..1630635 - 693 WP_026749259.1 50S ribosome-binding GTPase -
JMUB4039_RS07585 1630791..1631087 - 297 WP_036095739.1 4Fe-4S cluster-binding domain-containing protein -
JMUB4039_RS07590 1631089..1631931 - 843 WP_051354461.1 50S ribosome-binding GTPase -
JMUB4039_RS07595 1632135..1632296 - 162 WP_155282859.1 hypothetical protein -
JMUB4039_RS07600 1632410..1632694 - 285 WP_026749261.1 hypothetical protein -
JMUB4039_RS07605 1633622..1634629 - 1008 WP_036095732.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JMUB4039_RS07610 1634708..1635004 - 297 WP_021770172.1 type II toxin-antitoxin system YafQ family toxin Toxin
JMUB4039_RS07615 1634994..1635284 - 291 WP_026749263.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMUB4039_RS07620 1635359..1636300 - 942 WP_026749264.1 Abi family protein -
JMUB4039_RS07625 1636494..1638206 - 1713 WP_026749265.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(11-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-72)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11373.52 Da        Isoelectric Point: 10.0837

>T33160 WP_021770172.1 NZ_AP019831:c1635004-1634708 [Leptotrichia trevisanii]
MKGKKEEYKYSIILTGKFKKHLKNLKKQKKDLKLLESIISILAKGEKLPPKNKDHKLVNNYDGARECHITPDWLLIYEIV
EDKLILILLASGSHSELF

Download         Length: 297 bp

>T33160 NZ_AP019831:c1635004-1634708 [Leptotrichia trevisanii]
ATGAAGGGTAAAAAAGAAGAGTATAAATATTCTATTATTCTTACTGGGAAATTTAAAAAACATTTAAAAAATCTAAAAAA
ACAGAAAAAAGATTTAAAATTATTAGAAAGTATAATCTCAATATTAGCAAAAGGAGAAAAACTTCCTCCTAAAAACAAGG
ATCATAAATTAGTCAATAATTATGATGGGGCAAGAGAATGTCATATAACTCCAGATTGGTTATTAATCTACGAGATAGTT
GAAGATAAATTAATATTGATTTTATTAGCATCAGGTAGTCATAGTGAACTATTCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10909.37 Da        Isoelectric Point: 4.7049

>AT33160 WP_026749263.1 NZ_AP019831:c1635284-1634994 [Leptotrichia trevisanii]
MATVNTSIKIDEETKKEAQKLFKDLGLSLSTAINIFLKQAIREKGIPFYINSLPENSELAQAFEEVKQIKKNPSNYKSYS
SPEEMFKDVLGEDYEG

Download         Length: 291 bp

>AT33160 NZ_AP019831:c1635284-1634994 [Leptotrichia trevisanii]
ATGGCAACAGTTAATACAAGTATAAAGATAGATGAGGAAACTAAAAAAGAAGCACAGAAATTATTTAAAGATTTAGGATT
AAGCCTTAGTACAGCAATTAATATATTTTTAAAACAGGCTATAAGAGAAAAAGGCATACCATTTTATATAAATTCTTTAC
CTGAAAATTCAGAATTGGCTCAAGCATTTGAAGAAGTTAAACAAATTAAGAAAAATCCTTCAAATTATAAATCCTACAGT
AGTCCAGAAGAAATGTTTAAAGATGTCTTGGGAGAAGATTATGAAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510K1T3

Antitoxin

Source ID Structure
AlphaFold DB A0A510L0E3

References