Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 7428..7900 Replicon plasmid pJCM16777-1
Accession NZ_AP019830
Organism Leptotrichia wadei strain JCM16777

Toxin (Protein)


Gene name relE Uniprot ID A0A7U6QZZ4
Locus tag FVE73_RS10635 Protein ID WP_018499565.1
Coordinates 7628..7900 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C9N208
Locus tag FVE73_RS10630 Protein ID WP_006806162.1
Coordinates 7428..7643 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE73_RS10600 2746..4284 - 1539 WP_018498934.1 ATP-binding protein -
FVE73_RS10605 4285..4452 - 168 WP_018450743.1 helix-turn-helix transcriptional regulator -
FVE73_RS10610 4508..4822 - 315 WP_018498935.1 type II toxin-antitoxin system RelE/ParE family toxin -
FVE73_RS10615 4822..5049 - 228 WP_018498936.1 hypothetical protein -
FVE73_RS10620 5375..5992 + 618 WP_018498937.1 recombinase family protein -
FVE73_RS10625 6019..6189 + 171 WP_018498938.1 hypothetical protein -
FVE73_RS10630 7428..7643 + 216 WP_006806162.1 hypothetical protein Antitoxin
FVE73_RS10635 7628..7900 + 273 WP_018499565.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVE73_RS10640 8173..9600 - 1428 WP_146997897.1 hypothetical protein -
FVE73_RS10645 10762..11688 - 927 WP_026239072.1 replication initiation protein -
FVE73_RS10650 12018..12662 - 645 WP_018498919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..32202 32202


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10676.57 Da        Isoelectric Point: 10.9120

>T33158 WP_018499565.1 NZ_AP019830:7628-7900 [Leptotrichia wadei]
MGRTVKYKIIPTPHFAKDFSKLDEFVKKRIKIYLENITKDPRSKGKMLKANRKGQWRYRIGDFRVIVNIQDENLVVLALE
VGHRKNIYNS

Download         Length: 273 bp

>T33158 NZ_AP019830:7628-7900 [Leptotrichia wadei]
ATGGGAAGAACTGTAAAATATAAAATAATCCCAACTCCACATTTCGCAAAAGACTTTAGCAAACTAGATGAATTTGTAAA
AAAAAGAATAAAAATTTATTTAGAAAATATTACAAAAGATCCACGCAGTAAAGGAAAAATGTTGAAAGCAAATAGAAAAG
GACAATGGAGATACAGAATAGGAGATTTCAGAGTTATTGTAAATATCCAAGATGAAAATTTAGTAGTATTAGCGTTAGAA
GTAGGACATAGAAAAAATATTTATAATAGTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8155.29 Da        Isoelectric Point: 4.2346

>AT33158 WP_006806162.1 NZ_AP019830:7428-7643 [Leptotrichia wadei]
MASISLKVSDMEKKFLQSMAQFEGVTLSELIKSKVFDSLEDEYDAKIADLRLSEYESYLKNGGEVLKWEEL

Download         Length: 216 bp

>AT33158 NZ_AP019830:7428-7643 [Leptotrichia wadei]
ATGGCTTCTATAAGTTTAAAAGTGTCCGATATGGAAAAAAAATTTTTGCAAAGTATGGCACAATTTGAAGGAGTTACATT
GTCAGAGTTAATAAAATCAAAAGTGTTTGACTCACTAGAAGATGAATACGATGCCAAAATAGCAGATTTAAGATTATCAG
AATATGAAAGCTATTTGAAAAATGGAGGAGAAGTTTTAAAATGGGAAGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6QZZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A510KIG5

References