Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1148157..1148733 Replicon chromosome
Accession NZ_AP019829
Organism Leptotrichia wadei strain JCM16777

Toxin (Protein)


Gene name relE Uniprot ID A0A7U6LAL6
Locus tag FVE73_RS05395 Protein ID WP_018498034.1
Coordinates 1148157..1148453 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U6QZ79
Locus tag FVE73_RS05400 Protein ID WP_018498035.1
Coordinates 1148443..1148733 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE73_RS05375 1144187..1144837 - 651 WP_175284484.1 hypothetical protein -
FVE73_RS05380 1144850..1145881 - 1032 Protein_1046 hypothetical protein -
FVE73_RS05385 1146337..1147068 - 732 WP_018498032.1 YaaA family protein -
FVE73_RS05390 1147072..1148076 - 1005 WP_018498033.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
FVE73_RS05395 1148157..1148453 - 297 WP_018498034.1 type II toxin-antitoxin system YafQ family toxin Toxin
FVE73_RS05400 1148443..1148733 - 291 WP_018498035.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FVE73_RS05405 1148809..1149757 - 949 Protein_1051 Abi family protein -
FVE73_RS05410 1150052..1151110 - 1059 WP_018498037.1 hypothetical protein -
FVE73_RS05415 1151139..1152608 - 1470 WP_018498038.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(11-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-74)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11373.48 Da        Isoelectric Point: 10.1031

>T33157 WP_018498034.1 NZ_AP019829:c1148453-1148157 [Leptotrichia wadei]
MRGKKEEYKYSIILTGKFKKHLKNLKKQKKDLKLLESIISILAKGEKLPPKNKDHKLVNNYDGARECHITPDWLLIYEIA
EDKLILILLASGSHSELF

Download         Length: 297 bp

>T33157 NZ_AP019829:c1148453-1148157 [Leptotrichia wadei]
ATGAGGGGTAAAAAAGAAGAGTATAAATATTCTATTATTCTTACTGGGAAATTTAAAAAACATTTAAAAAATCTAAAAAA
ACAGAAAAAAGATTTAAAATTATTAGAAAGTATAATCTCAATATTAGCAAAAGGAGAAAAACTTCCTCCTAAAAACAAGG
ATCATAAATTAGTCAATAATTATGATGGGGCAAGAGAATGTCATATAACTCCAGATTGGTTATTAATCTATGAGATAGCT
GAAGATAAATTAATATTGATTTTATTAGCATCAGGTAGTCATAGTGAATTATTCTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10867.29 Da        Isoelectric Point: 4.6936

>AT33157 WP_018498035.1 NZ_AP019829:c1148733-1148443 [Leptotrichia wadei]
MATVNTSIKIDEETKKEAQKLFKDLGLSLSTAINIFLKQAIREKGIPFYINSLPENSELAQAFEEAKQIKKNPSNYKSYS
SPEDMFKDVLGEDYEG

Download         Length: 291 bp

>AT33157 NZ_AP019829:c1148733-1148443 [Leptotrichia wadei]
ATGGCAACAGTTAATACAAGTATAAAGATAGATGAAGAAACTAAAAAAGAAGCACAGAAATTATTTAAAGATTTAGGATT
AAGCCTTAGTACAGCAATTAATATATTTTTGAAACAAGCTATAAGAGAAAAAGGCATACCATTTTATATAAATTCTTTAC
CTGAAAATTCAGAATTGGCTCAAGCATTTGAAGAAGCTAAACAAATTAAGAAAAATCCTTCAAATTATAAATCTTACAGT
AGTCCAGAAGATATGTTTAAAGATGTCTTGGGAGAAGATTATGAGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U6LAL6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U6QZ79

References