Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 13054..13526 Replicon plasmid JCM16776p1
Accession NZ_AP019828
Organism Leptotrichia shahii strain JCM16776

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag F1564_RS10040 Protein ID WP_149201971.1
Coordinates 13254..13526 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F1564_RS10035 Protein ID WP_149201970.1
Coordinates 13054..13269 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1564_RS10005 9036..9203 - 168 WP_018450743.1 helix-turn-helix transcriptional regulator -
F1564_RS10010 9259..9582 - 324 WP_149201968.1 type II toxin-antitoxin system RelE/ParE family toxin -
F1564_RS10015 9582..9809 - 228 WP_018498936.1 hypothetical protein -
F1564_RS10020 10188..10835 + 648 WP_018450730.1 recombinase family protein -
F1564_RS10025 11017..11466 + 450 WP_018450729.1 type II toxin-antitoxin system PemK/MazF family toxin -
F1564_RS10030 11651..11839 + 189 WP_149201969.1 hypothetical protein -
F1564_RS10035 13054..13269 + 216 WP_149201970.1 antitoxin Antitoxin
F1564_RS10040 13254..13526 + 273 WP_149201971.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F1564_RS10045 13660..14622 - 963 WP_149201972.1 replication initiation protein -
F1564_RS10050 15183..15449 + 267 WP_083917115.1 plasmid mobilization relaxosome protein MobC -
F1564_RS10055 15655..17697 + 2043 WP_018450723.1 hypothetical protein -
F1564_RS10060 17699..18220 - 522 Protein_21 DNA adenine methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18220 18220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10658.53 Da        Isoelectric Point: 10.6267

>T33156 WP_149201971.1 NZ_AP019828:13254-13526 [Leptotrichia shahii]
MGRSVKYKIIPTPHFVKDFNKLDEFVKKRIKIYLENIAEDPRSKGKMLKANRKGQWRYRIGDYRVIVNIQDENLVILALE
VGHRKNICNS

Download         Length: 273 bp

>T33156 NZ_AP019828:13254-13526 [Leptotrichia shahii]
ATGGGAAGAAGTGTAAAATATAAAATAATCCCAACTCCACATTTCGTAAAAGATTTTAACAAACTGGATGAATTTGTAAA
AAAAAGAATAAAAATTTATTTAGAAAATATTGCAGAAGATCCACGCAGTAAAGGAAAAATGTTGAAAGCAAATAGAAAAG
GACAATGGAGATACAGAATAGGAGATTACAGAGTTATTGTAAATATTCAAGATGAGAACTTAGTAATATTAGCACTAGAA
GTAGGACATAGAAAAAATATTTGTAATAGTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8141.26 Da        Isoelectric Point: 4.2346

>AT33156 WP_149201970.1 NZ_AP019828:13054-13269 [Leptotrichia shahii]
MASISLKVSDMEKKFLQSMAQFEGVTLSELIKSKVFDSLEDEYDAKIADLRLSEYESYLKNGGEVLKWEEV

Download         Length: 216 bp

>AT33156 NZ_AP019828:13054-13269 [Leptotrichia shahii]
ATGGCTTCTATAAGTTTAAAAGTGTCTGATATGGAAAAAAAATTTTTGCAAAGTATGGCACAATTTGAAGGTGTTACATT
GTCAGAGTTAATAAAATCAAAAGTGTTTGACTCACTGGAAGATGAATATGATGCCAAAATAGCAGATTTACGATTATCAG
AATATGAAAGCTATTTGAAAAATGGAGGAGAAGTTTTAAAATGGGAAGAAGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References