Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1544..2016 Replicon plasmid JCM16776p1
Accession NZ_AP019828
Organism Leptotrichia shahii strain JCM16776

Toxin (Protein)


Gene name relE Uniprot ID A0A510JQW9
Locus tag F1564_RS09965 Protein ID WP_018450732.1
Coordinates 1744..2016 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C9N208
Locus tag F1564_RS09960 Protein ID WP_006806162.1
Coordinates 1544..1759 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1564_RS09955 2..970 + 969 Protein_0 ISLre2 family transposase -
F1564_RS09960 1544..1759 + 216 WP_006806162.1 hypothetical protein Antitoxin
F1564_RS09965 1744..2016 + 273 WP_018450732.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F1564_RS09970 2358..3251 + 894 WP_018450733.1 Fic family protein -
F1564_RS09975 3667..3825 - 159 WP_018450735.1 RepB family plasmid replication initiator protein -
F1564_RS09980 4141..4404 - 264 WP_026231257.1 Txe/YoeB family addiction module toxin -
F1564_RS09985 4397..4651 - 255 WP_018450737.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
F1564_RS09990 5184..6188 + 1005 WP_018450738.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18220 18220
- flank IS/Tn - - 44..970 926


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10690.56 Da        Isoelectric Point: 10.7635

>T33155 WP_018450732.1 NZ_AP019828:1744-2016 [Leptotrichia shahii]
MGRTVKYKIIPTPHFVKNFSKLDEFVKKRIKIYLENIAEDPRSKGKMLKANRKGQWRYRIGDYRVIVNIQDENLVVLALE
VGHRKNIYNS

Download         Length: 273 bp

>T33155 NZ_AP019828:1744-2016 [Leptotrichia shahii]
ATGGGAAGAACTGTAAAATATAAAATAATCCCAACTCCACATTTCGTAAAAAACTTTAGCAAACTAGATGAATTTGTAAA
AAAAAGAATAAAAATTTATTTAGAAAATATTGCAGAAGATCCACGCAGTAAAGGAAAAATGTTGAAAGCAAATAGAAAAG
GACAATGGAGATACAGAATAGGAGATTACAGAGTTATTGTAAATATTCAAGATGAAAATTTAGTAGTATTAGCGTTAGAA
GTAGGGCATAGAAAAAATATTTATAATAGTTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8155.29 Da        Isoelectric Point: 4.2346

>AT33155 WP_006806162.1 NZ_AP019828:1544-1759 [Leptotrichia shahii]
MASISLKVSDMEKKFLQSMAQFEGVTLSELIKSKVFDSLEDEYDAKIADLRLSEYESYLKNGGEVLKWEEL

Download         Length: 216 bp

>AT33155 NZ_AP019828:1544-1759 [Leptotrichia shahii]
ATGGCTTCTATAAGTTTAAAGGTGTCTGATATGGAAAAAAAATTTTTGCAAAGTATGGCACAATTTGAAGGAGTTACATT
GTCAGAGTTAATAAAATCAAAAGTGTTTGACTCACTAGAAGATGAATATGATGCCAAAATAGCAGATTTAAGATTATCAG
AATATGAAAGCTATTTGAAAAATGGAGGAGAAGTTTTAAAATGGGAAGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510JQW9

Antitoxin

Source ID Structure
AlphaFold DB A0A510KIG5

References