33152

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09907-MazE
Location 425849..426423 Replicon chromosome
Accession NZ_AP019827
Organism Leptotrichia shahii strain JCM16776

Toxin (Protein)


Gene name mazF Uniprot ID A0A510JRA4
Locus tag F1564_RS02055 Protein ID WP_018450841.1
Coordinates 426094..426423 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A510L2B8
Locus tag F1564_RS02050 Protein ID WP_018450842.1
Coordinates 425849..426100 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1564_RS02030 421457..421915 - 459 WP_018450846.1 DIP1984 family protein -
F1564_RS02035 422172..423221 + 1050 WP_018450845.1 heat-inducible transcriptional repressor HrcA -
F1564_RS02040 423203..423769 + 567 WP_018450844.1 nucleotide exchange factor GrpE -
F1564_RS02045 423889..425712 + 1824 WP_018450843.1 molecular chaperone DnaK -
F1564_RS02050 425849..426100 + 252 WP_018450842.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F1564_RS02055 426094..426423 + 330 WP_018450841.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
F1564_RS02060 426502..427383 + 882 WP_018450840.1 aldose 1-epimerase family protein -
F1564_RS02065 427569..428054 + 486 WP_018450839.1 hypothetical protein -
F1564_RS02070 428149..429330 + 1182 WP_018450838.1 molecular chaperone DnaJ -
F1564_RS02075 429555..430565 + 1011 WP_018450837.1 ketol-acid reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-100)

Antitoxin

Antitoxin PemI-like

(5-83)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12404.53 Da        Isoelectric Point: 6.2213

>T33152 WP_018450841.1 NZ_AP019827:426094-426423 [Leptotrichia shahii]
MVKQGDIIKINFNPQMGHEQAGYRPAVIVSNGTFNRVTNLVLVCPITDSIDKFPLHIKLDNRTATMGIILCEHLKSLDIN
KRSYKIIEKLPEDILEKVVDIIFSEIEIE

Download         Length: 330 bp

>T33152 NZ_AP019827:426094-426423 [Leptotrichia shahii]
ATGGTAAAACAAGGGGATATAATAAAGATAAATTTTAATCCGCAGATGGGACATGAACAAGCTGGATATCGTCCTGCGGT
TATAGTAAGTAATGGTACTTTCAATAGGGTAACAAATTTAGTTTTAGTTTGTCCAATTACAGATTCAATAGACAAATTTC
CGCTTCATATAAAATTAGACAATCGGACTGCTACGATGGGCATAATTTTATGTGAACACCTTAAATCTTTGGATATTAAT
AAAAGAAGTTATAAAATTATTGAAAAATTACCAGAGGATATTTTAGAAAAAGTCGTAGACATTATTTTTTCAGAAATAGA
AATTGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9814.46 Da        Isoelectric Point: 7.9594

>AT33152 WP_018450842.1 NZ_AP019827:425849-426100 [Leptotrichia shahii]
MAEVLKIQKWGNSQGIRLPKKILEILDLKVNDTILIEEGDNCLKLKKIKKEKRKTIKELFANYNEDYEKQEIDWGEPVGK
EVW

Download         Length: 252 bp

>AT33152 NZ_AP019827:425849-426100 [Leptotrichia shahii]
ATGGCAGAGGTTTTAAAAATACAAAAATGGGGAAACAGTCAGGGAATAAGACTTCCTAAAAAAATATTGGAAATACTTGA
TTTAAAAGTAAATGATACTATTTTGATAGAAGAGGGAGATAATTGCCTTAAATTAAAAAAAATAAAAAAAGAAAAAAGAA
AGACAATAAAGGAATTGTTTGCAAATTATAATGAGGATTATGAAAAACAGGAAATAGATTGGGGAGAACCAGTAGGTAAA
GAGGTATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510JRA4

Antitoxin

Source ID Structure
AlphaFold DB A0A510L2B8

References