Detailed information of TA system TA033151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 326082..326646
• Replicon: chromosome
• Accession: NZ_AP019827
• Organism: Leptotrichia shahii strain JCM16776

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F1564_RS01550
• Protein ID: WP_026231269.1
• Coordinates: 326082..326360 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A510JR00
• Locus tag: F1564_RS01555
• Protein ID: WP_018450943.1
• Coordinates: 326368..326646 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F1564_RS01520	321111..321296	-	186	WP_149201947.1	hypothetical protein	-
F1564_RS10070	321357..321506	-	150	WP_018450951.1	hypothetical protein	-
F1564_RS01525	321585..322454	-	870	WP_018450950.1	hypothetical protein	-
F1564_RS01530	322435..322674	-	240	WP_149201948.1	hypothetical protein	-
F1564_RS01535	322698..323021	-	324	WP_018450948.1	hypothetical protein	-
F1564_RS01540	323224..323427	-	204	WP_018450946.1	hypothetical protein	-
F1564_RS01545	323605..324336	+	732	WP_018450945.1	helix-turn-helix transcriptional regulator	-
F1564_RS01550	326082..326360	-	279	WP_026231269.1	type II toxin-antitoxin system YafQ family toxin	Toxin
F1564_RS01555	326368..326646	-	279	WP_018450943.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
F1564_RS10075	327693..327836	-	144	WP_018450942.1	hypothetical protein	-
F1564_RS01560	327966..328578	-	613	Protein_286	site-specific integrase	-
F1564_RS01565	329252..329443	-	192	Protein_287	XRE family transcriptional regulator	-
F1564_RS01570	329558..329893	+	336	WP_018450939.1	helix-turn-helix domain-containing protein	-
F1564_RS01575	330152..330478	-	327	WP_018450938.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
F1564_RS01580	330799..331032	-	234	WP_018450937.1	IS30 family transposase	-
F1564_RS10145	330968..331153	-	186	WP_169333547.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10639.34 Da
• Isoelectric Point: 8.8944

>T33151 WP_026231269.1 NZ_AP019827:c326360-326082 [Leptotrichia shahii]
MIYSIHTTKQFRKSLKRVERRGYNTSLLNEVIEMLAKGEKLPEKNKDHSLIGDYVGHRECHIAPDWLLIYKITEKGLILL
LTDTGTHSDLFG

Nucleotide

• Length: 279 bp

>T33151 NZ_AP019827:c326360-326082 [Leptotrichia shahii]
ATGATATACTCGATACATACAACTAAACAATTTCGCAAAAGTTTGAAACGTGTAGAAAGACGTGGATATAATACAAGTTT
ATTAAATGAAGTTATAGAAATGCTGGCAAAAGGGGAGAAGTTACCTGAAAAGAATAAAGACCATTCTTTGATAGGAGACT
ATGTAGGACATCGTGAGTGCCATATAGCACCTGATTGGCTATTGATATACAAGATAACAGAAAAGGGCTTGATACTGTTA
TTAACAGATACAGGAACTCACAGCGACCTATTTGGATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10502.99 Da
• Isoelectric Point: 4.4879

>AT33151 WP_018450943.1 NZ_AP019827:c326646-326368 [Leptotrichia shahii]
MSATTINIDDTTKKEAQELFKDLGMNLTTAINIFLKQAIKEQKIPFEIRNPRPRQELLAAIKEAEEMERTGNMGKGYSSA
KEMIEDILENEE

Nucleotide

• Length: 279 bp

>AT33151 NZ_AP019827:c326646-326368 [Leptotrichia shahii]
ATGAGTGCAACAACTATAAATATAGATGATACTACTAAAAAAGAAGCACAGGAGTTATTTAAGGACTTAGGAATGAACTT
AACTACAGCGATAAACATATTCTTAAAACAGGCAATAAAAGAACAGAAGATACCTTTTGAAATTAGGAATCCACGCCCAA
GACAAGAGTTATTGGCTGCTATTAAAGAGGCGGAAGAAATGGAAAGAACTGGCAATATGGGTAAAGGTTATTCGTCAGCA
AAAGAAATGATAGAGGACATACTGGAAAATGAAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A510JR00