Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 15568..16040 Replicon plasmid pJCM16775-1
Accession NZ_AP019824
Organism Leptotrichia hofstadii strain JCM16775

Toxin (Protein)


Gene name relE Uniprot ID U2RV34
Locus tag FVE77_RS12150 Protein ID WP_021745737.1
Coordinates 15568..15840 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C9N208
Locus tag FVE77_RS12155 Protein ID WP_006806162.1
Coordinates 15825..16040 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE77_RS12140 13436..14113 + 678 WP_146967971.1 hypothetical protein -
FVE77_RS12145 14514..15434 + 921 WP_036087326.1 replication initiation protein -
FVE77_RS12150 15568..15840 - 273 WP_021745737.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVE77_RS12155 15825..16040 - 216 WP_006806162.1 hypothetical protein Antitoxin
FVE77_RS12725 17262..17450 - 189 WP_172966428.1 hypothetical protein -
FVE77_RS12160 17635..18138 - 504 WP_026745118.1 type II toxin-antitoxin system PemK/MazF family toxin -
FVE77_RS12165 18247..18912 - 666 WP_026745119.1 recombinase family protein -
FVE77_RS12520 19208..19378 + 171 WP_154669765.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..34135 34135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-88)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10691.54 Da        Isoelectric Point: 10.6516

>T33150 WP_021745737.1 NZ_AP019824:c15840-15568 [Leptotrichia hofstadii]
MGRTVKYKIIPTPHFVKDFSKLDEFVKKRIKIYLENIAEDPRSKGKMLKANRKGQWRYRIGDYRVIVNIQDENLVVLALE
VGHRKNIYNS

Download         Length: 273 bp

>T33150 NZ_AP019824:c15840-15568 [Leptotrichia hofstadii]
ATGGGAAGAACTGTAAAATATAAAATAATCCCAACTCCACATTTCGTAAAAGACTTTAGCAAACTAGATGAATTTGTAAA
AAAAAGAATAAAAATTTATTTAGAAAATATTGCAGAAGATCCACGCAGTAAAGGAAAAATGTTGAAAGCAAATAGAAAAG
GACAATGGAGATACAGAATAGGAGATTACAGAGTTATTGTAAATATCCAAGATGAAAATTTAGTAGTATTAGCGTTAGAA
GTAGGACATAGAAAAAATATTTATAATAGTTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8155.29 Da        Isoelectric Point: 4.2346

>AT33150 WP_006806162.1 NZ_AP019824:c16040-15825 [Leptotrichia hofstadii]
MASISLKVSDMEKKFLQSMAQFEGVTLSELIKSKVFDSLEDEYDAKIADLRLSEYESYLKNGGEVLKWEEL

Download         Length: 216 bp

>AT33150 NZ_AP019824:c16040-15825 [Leptotrichia hofstadii]
ATGGCTTCTATAAGTTTAAAAGTATCTGATATGGAAAAAAAATTTTTGCAAAGTATGGCGCAATTTGAAGGAGTTACATT
GTCAGAGTTAATAAAATCAAAAGTGTTTGACTCACTAGAAGATGAATACGATGCCAAAATAGCAGATTTAAGATTATCAG
AATATGAAAGCTATTTGAAAAATGGAGGAGAAGTTTTAAAATGGGAAGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510KH77

Antitoxin

Source ID Structure
AlphaFold DB A0A510KIG5

References