Detailed information of TA system TA033146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1255175..1255715
• Replicon: chromosome
• Accession: NZ_AP019823
• Organism: Leptotrichia hofstadii strain JCM16775

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FVE77_RS05870
• Protein ID: WP_006804297.1
• Coordinates: 1255443..1255715 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2WEA4
• Locus tag: FVE77_RS05865
• Protein ID: WP_006804298.1
• Coordinates: 1255175..1255450 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE77_RS05835	1250213..1250620	+	408	WP_026746388.1	DUF1232 domain-containing protein	-
FVE77_RS05840	1250633..1251529	+	897	WP_026746387.1	RNA-binding protein S4	-
FVE77_RS05845	1251597..1251779	+	183	WP_026746386.1	hypothetical protein	-
FVE77_RS05850	1251899..1253698	+	1800	WP_026746385.1	oligoendopeptidase F	-
FVE77_RS12645	1253859..1254020	+	162	WP_162141763.1	hypothetical protein	-
FVE77_RS05855	1254252..1254527	+	276	WP_006804298.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
FVE77_RS05860	1254520..1254792	+	273	WP_006804297.1	type II toxin-antitoxin system YafQ family toxin	-
FVE77_RS05865	1255175..1255450	+	276	WP_006804298.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FVE77_RS05870	1255443..1255715	+	273	WP_006804297.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FVE77_RS05875	1256100..1256375	+	276	WP_026746383.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
FVE77_RS05880	1256368..1256640	+	273	WP_197735417.1	type II toxin-antitoxin system YafQ family toxin	-
FVE77_RS05885	1256713..1257081	+	369	WP_026746381.1	hypothetical protein	-
FVE77_RS05890	1257133..1257945	-	813	WP_026746380.1	phospholipase D family protein	-
FVE77_RS05895	1257917..1258828	-	912	WP_036087935.1	lipase	-
FVE77_RS05900	1258846..1259619	-	774	WP_026746379.1	type III pantothenate kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10692.67 Da
• Isoelectric Point: 10.0230

>T33146 WP_006804297.1 NZ_AP019823:1255443-1255715 [Leptotrichia hofstadii]
VYKIKFTGQFKKELKLAKKQGKDINKLFKIVDILAQKKVLDIKYKDHALISNYKGFRECHIEPDWLLIYKYYDDILVLSL
SRLGSHSELF

Nucleotide

• Length: 273 bp

>T33146 NZ_AP019823:1255443-1255715 [Leptotrichia hofstadii]
GTGTATAAAATTAAATTTACAGGACAATTCAAGAAAGAATTGAAATTAGCCAAAAAGCAAGGAAAAGATATTAATAAATT
ATTTAAAATCGTTGATATTTTAGCTCAAAAGAAAGTATTAGACATTAAATATAAAGATCATGCATTAATCAGTAATTACA
AAGGATTCAGAGAATGCCATATTGAACCTGATTGGCTATTAATATATAAATATTATGATGACATTTTAGTATTATCCTTA
TCTCGTTTAGGTTCACACTCAGAACTGTTTTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10419.84 Da
• Isoelectric Point: 4.5117

>AT33146 WP_006804298.1 NZ_AP019823:1255175-1255450 [Leptotrichia hofstadii]
MANANLSIRVDKETKEKANELFNKFGLTMTTAVNMFLKTAIRENRIPFELKLEEEPNEVTLEAMREADRIARDDSVKGYD
SIEELREALGV

Nucleotide

• Length: 276 bp

>AT33146 NZ_AP019823:1255175-1255450 [Leptotrichia hofstadii]
ATGGCAAATGCAAATTTAAGTATTAGAGTTGATAAAGAAACAAAAGAAAAAGCGAATGAATTATTTAACAAATTTGGATT
GACAATGACAACCGCAGTAAATATGTTCTTAAAAACTGCAATTAGGGAAAATAGAATCCCTTTTGAATTGAAATTGGAAG
AAGAGCCAAATGAAGTGACTTTAGAAGCAATGAGAGAAGCTGATAGAATTGCAAGAGATGATAGTGTAAAGGGATATGAC
AGCATAGAGGAGTTGAGAGAGGCACTTGGTGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A510L0M7