Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 563290..563834 Replicon chromosome
Accession NZ_AP019822
Organism Pseudoleptotrichia goodfellowii strain JCM16774

Toxin (Protein)


Gene name relE Uniprot ID A0A510J917
Locus tag FVE72_RS02865 Protein ID WP_026737179.1
Coordinates 563559..563834 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0GJP2
Locus tag FVE72_RS02860 Protein ID WP_006806688.1
Coordinates 563290..563562 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE72_RS02840 558669..559553 - 885 WP_051411731.1 hypothetical protein -
FVE72_RS02845 559622..560110 - 489 WP_026737176.1 hypothetical protein -
FVE72_RS02850 560327..561799 + 1473 WP_026737177.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase -
FVE72_RS02855 561859..562917 + 1059 WP_026737178.1 extracellular solute-binding protein -
FVE72_RS02860 563290..563562 + 273 WP_006806688.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FVE72_RS02865 563559..563834 + 276 WP_026737179.1 type II toxin-antitoxin system YafQ family toxin Toxin
FVE72_RS02870 563883..564749 - 867 WP_026737180.1 methylenetetrahydrofolate reductase [NAD(P)H] -
FVE72_RS02875 565025..565831 - 807 WP_026737181.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
FVE72_RS02880 566081..566827 + 747 WP_026737182.1 Fe-S cluster assembly ATPase SufC -
FVE72_RS02885 566858..568273 + 1416 WP_026737183.1 Fe-S cluster assembly protein SufB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-88)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10807.68 Da        Isoelectric Point: 9.5837

>T33143 WP_026737179.1 NZ_AP019822:563559-563834 [Pseudoleptotrichia goodfellowii]
MKYKVKFTGQFKKDLKLLKKQGKDVDKLFEVIEILANGKKLKEKYREHNLTGNYKGTKECHVDPDWLLIYEFYDDILVLL
LLRTGSHSELF

Download         Length: 276 bp

>T33143 NZ_AP019822:563559-563834 [Pseudoleptotrichia goodfellowii]
ATGAAATATAAAGTTAAATTTACAGGGCAATTTAAAAAAGATTTGAAATTATTAAAAAAACAGGGCAAAGATGTAGATAA
ATTGTTTGAAGTTATTGAAATTTTAGCAAATGGAAAAAAATTGAAAGAAAAATATAGAGAACATAATTTAACAGGAAATT
ATAAAGGTACCAAAGAATGCCATGTTGATCCGGATTGGCTGTTAATATATGAATTTTATGATGATATATTAGTTCTCCTG
TTATTGCGTACAGGTTCCCATTCCGAACTTTTTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10095.76 Da        Isoelectric Point: 8.6145

>AT33143 WP_006806688.1 NZ_AP019822:563290-563562 [Pseudoleptotrichia goodfellowii]
MANTNLNIRTDIDVKKKANAIFQELGMSMTTAVNLFLKTAIRENGIPFSLKLETPNEMTIKAIEEGRKIAENKEIEGFSN
IKDLKKALEV

Download         Length: 273 bp

>AT33143 NZ_AP019822:563290-563562 [Pseudoleptotrichia goodfellowii]
ATGGCAAACACAAATTTAAATATTCGAACGGACATTGATGTGAAAAAAAAGGCAAATGCGATATTTCAGGAACTTGGAAT
GTCAATGACAACAGCTGTTAATTTATTTCTTAAAACTGCTATAAGAGAAAATGGGATACCTTTTTCATTGAAATTGGAAA
CACCGAATGAAATGACTATTAAAGCAATAGAAGAAGGTAGAAAAATTGCTGAAAATAAAGAAATTGAGGGGTTTTCAAAT
ATTAAAGATTTGAAAAAAGCACTTGAAGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510J917

Antitoxin

Source ID Structure
AlphaFold DB A0A510JC67

References