Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3710147..3710804 Replicon chromosome
Accession NZ_AP019817
Organism Enterobacter hormaechei subsp. hoffmannii strain OIPH-N069

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag G7Y81_RS17555 Protein ID WP_022649305.1
Coordinates 3710147..3710557 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag G7Y81_RS17560 Protein ID WP_003863437.1
Coordinates 3710538..3710804 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y81_RS17535 3706145..3707878 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
G7Y81_RS17540 3707884..3708597 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G7Y81_RS17545 3708626..3709522 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
G7Y81_RS17550 3709624..3710145 + 522 WP_015571793.1 flavodoxin FldB -
G7Y81_RS17555 3710147..3710557 - 411 WP_022649305.1 protein YgfX Toxin
G7Y81_RS17560 3710538..3710804 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
G7Y81_RS17565 3711099..3712079 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
G7Y81_RS17570 3712603..3713262 - 660 WP_022649307.1 hemolysin III family protein -
G7Y81_RS17575 3713529..3714260 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T33139 WP_022649305.1 NZ_AP019817:c3710557-3710147 [Enterobacter hormaechei subsp. hoffmannii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T33139 NZ_AP019817:c3710557-3710147 [Enterobacter hormaechei subsp. hoffmannii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT33139 WP_003863437.1 NZ_AP019817:c3710804-3710538 [Enterobacter hormaechei subsp. hoffmannii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT33139 NZ_AP019817:c3710804-3710538 [Enterobacter hormaechei subsp. hoffmannii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References