Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3443288..3444027 Replicon chromosome
Accession NZ_AP019817
Organism Enterobacter hormaechei subsp. hoffmannii strain OIPH-N069

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag G7Y81_RS16285 Protein ID WP_022649088.1
Coordinates 3443647..3444027 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag G7Y81_RS16280 Protein ID WP_022649087.1
Coordinates 3443288..3443614 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y81_RS16265 3439182..3441842 - 2661 WP_022649084.1 hypothetical protein -
G7Y81_RS16270 3442376..3442795 + 420 Protein_3172 antirestriction protein -
G7Y81_RS16275 3442810..3443277 + 468 WP_022649086.1 DNA repair protein RadC -
G7Y81_RS16280 3443288..3443614 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G7Y81_RS16285 3443647..3444027 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
G7Y81_RS16290 3444024..3444251 + 228 WP_022649089.1 hypothetical protein -
G7Y81_RS16295 3444643..3444936 + 294 WP_022649090.1 hypothetical protein -
G7Y81_RS16300 3445280..3446596 - 1317 WP_022649091.1 amidase -
G7Y81_RS16305 3446651..3447946 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3420179..3444936 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T33138 WP_022649088.1 NZ_AP019817:3443647-3444027 [Enterobacter hormaechei subsp. hoffmannii]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T33138 NZ_AP019817:3443647-3444027 [Enterobacter hormaechei subsp. hoffmannii]
ATGCAAACTTTACCGTTACCCGAACCTCGGGCGGCTGAGCCATGTCCGTCGCCCGTGCAGGTCTGGCAACTCCTGCTCAC
GCATCTGCTGGATAAGCATTATGGTCTCACACTCAATGACACGCCGTTTGGCGACGACGGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCTCTGTGCGACGCCGTCAACTTCATTGTGGAAAGGTATGAACTGTTGCGCACTGACCACAGCAGCTCC
AGCCTCACCGAGCACTCTTCACTGATTGGTGCCATCGACATCCTGCGTGCCCACCGTGCAACCGGCCTGATAGTGGGCAG
CGGCTACAGCACCATCACCCGCATCACAACGGGCCAGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT33138 WP_022649087.1 NZ_AP019817:3443288-3443614 [Enterobacter hormaechei subsp. hoffmannii]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT33138 NZ_AP019817:3443288-3443614 [Enterobacter hormaechei subsp. hoffmannii]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAACGCCGTGCTTCAGTGCCAAGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTAGCTGACCGAGCAGAGTTTAGTGGCGACTTGAGCGACGATGAGGCACTGCGCCTCGACCAGGCTTTTCCGG
TGATATTGAAGCAGCTGGAACAAATGCTTTCAGCCGGTGAGCTGAATCCCCGCCATCAGCATCGCGTCACTCTGCATCTT
AACGGGCTAACCTGCGAAGCCGACACGCTCGGTTCGCACGGCTACCTTTACATCGCGATTTATCCCTCAGCGGTAGCTAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References