Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1081752..1082373 Replicon chromosome
Accession NZ_AP019817
Organism Enterobacter hormaechei subsp. hoffmannii strain OIPH-N069

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag G7Y81_RS05145 Protein ID WP_015571250.1
Coordinates 1081752..1081970 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag G7Y81_RS05150 Protein ID WP_006809850.1
Coordinates 1081999..1082373 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7Y81_RS05115 1077764..1078024 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
G7Y81_RS05120 1078027..1078167 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
G7Y81_RS05125 1078164..1078874 - 711 WP_022647267.1 GNAT family N-acetyltransferase -
G7Y81_RS05130 1078977..1080437 + 1461 WP_022647268.1 PLP-dependent aminotransferase family protein -
G7Y81_RS05135 1080409..1080876 - 468 WP_022647269.1 hypothetical protein -
G7Y81_RS05140 1080993..1081544 - 552 WP_022647270.1 maltose O-acetyltransferase -
G7Y81_RS05145 1081752..1081970 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
G7Y81_RS05150 1081999..1082373 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
G7Y81_RS05155 1082883..1086029 - 3147 WP_022647271.1 multidrug efflux RND transporter permease subunit -
G7Y81_RS05160 1086052..1087245 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T33128 WP_015571250.1 NZ_AP019817:c1081970-1081752 [Enterobacter hormaechei subsp. hoffmannii]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T33128 NZ_AP019817:c1081970-1081752 [Enterobacter hormaechei subsp. hoffmannii]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT33128 WP_006809850.1 NZ_AP019817:c1082373-1081999 [Enterobacter hormaechei subsp. hoffmannii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT33128 NZ_AP019817:c1082373-1081999 [Enterobacter hormaechei subsp. hoffmannii]
TTGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References