Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2050978..2051632 Replicon chromosome
Accession NZ_AP019814
Organism Enterococcus avium strain G-15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HZ312_RS10305 Protein ID WP_178982548.1
Coordinates 2051447..2051632 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZ312_RS10300 Protein ID WP_178982546.1
Coordinates 2050978..2051412 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ312_RS10280 2047471..2047872 + 402 WP_178982542.1 PTS sugar transporter subunit IIA -
HZ312_RS10285 2048086..2049393 - 1308 WP_178982001.1 ISL3 family transposase -
HZ312_RS10290 2049522..2050349 - 828 Protein_1991 DUF3991 and TOPRIM domain-containing protein -
HZ312_RS10295 2050422..2050862 - 441 WP_178982544.1 hypothetical protein -
HZ312_RS10300 2050978..2051412 - 435 WP_178982546.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HZ312_RS10305 2051447..2051632 - 186 WP_178982548.1 type II toxin-antitoxin system HicA family toxin Toxin
HZ312_RS10310 2051703..2052944 - 1242 WP_178982550.1 hypothetical protein -
HZ312_RS10315 2052947..2053495 - 549 WP_178982552.1 hypothetical protein -
HZ312_RS10320 2053495..2053881 - 387 WP_178982554.1 ribbon-helix-helix domain-containing protein -
HZ312_RS10325 2054115..2054930 - 816 WP_178982556.1 hypothetical protein -
HZ312_RS10330 2054952..2055329 - 378 WP_178982558.1 thioredoxin family protein -
HZ312_RS10335 2055383..2055997 - 615 WP_178982560.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2048086..2049393 1307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(10-122)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6968.12 Da        Isoelectric Point: 10.7089

>T33126 WP_178982548.1 NZ_AP019814:c2051632-2051447 [Enterococcus avium]
MPLTGKQMLKLLKKNGWIERRQEGSHHHLYKDGIRVTVPVHGNQDLGRGLEQQILKDAGLK

Download         Length: 186 bp

>T33126 NZ_AP019814:c2051632-2051447 [Enterococcus avium]
ATGCCACTTACAGGAAAACAAATGCTGAAGTTATTGAAAAAGAATGGTTGGATTGAACGTAGGCAAGAAGGATCTCATCA
TCATCTATATAAAGATGGTATCAGGGTCACAGTGCCAGTTCATGGTAATCAAGATCTTGGCCGAGGACTTGAACAGCAAA
TTTTGAAGGACGCGGGATTGAAATAA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 15862.24 Da        Isoelectric Point: 4.4729

>AT33126 WP_178982546.1 NZ_AP019814:c2051412-2050978 [Enterococcus avium]
VLSEPLAKTYPAVFQPEEGGGFFIKFPDIQGAYTGINEEDISYGLAMAEEVLGMVLADYIEHEDPLPKPTPIKEIKVDND
AFTTLIRVDVAKYLKDTELIKKTLTIPKWADTLGKRAGMNFSVLLTESIADKANDILLSNKSGK

Download         Length: 435 bp

>AT33126 NZ_AP019814:c2051412-2050978 [Enterococcus avium]
GTGTTGAGCGAACCTTTAGCTAAAACTTATCCAGCTGTATTTCAACCAGAAGAAGGTGGCGGATTCTTTATCAAGTTTCC
TGATATTCAAGGTGCATACACAGGAATTAATGAAGAAGATATTTCATATGGACTTGCAATGGCAGAAGAGGTACTTGGAA
TGGTCTTAGCTGATTATATTGAGCATGAAGATCCATTACCAAAACCAACACCAATTAAGGAAATAAAAGTTGATAATGAT
GCTTTTACTACATTAATTCGGGTGGATGTAGCGAAGTATTTAAAAGACACGGAATTGATCAAGAAGACTTTGACCATTCC
TAAATGGGCAGATACTTTAGGTAAGCGAGCAGGTATGAATTTTTCAGTTCTTCTAACAGAATCCATAGCGGATAAAGCAA
ATGATATTCTTCTGTCAAACAAATCTGGAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References