Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 63486..63967 Replicon plasmid pEM15-1A-1
Accession NZ_AP019811
Organism Enterococcus mundtii strain 15-1A

Toxin (Protein)


Gene name relE Uniprot ID A0A848MZZ8
Locus tag HZ311_RS15130 Protein ID WP_062806315.1
Coordinates 63486..63755 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A022N681
Locus tag HZ311_RS15135 Protein ID WP_034690365.1
Coordinates 63752..63967 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ311_RS15110 58950..59990 - 1041 WP_178946860.1 DUF916 and DUF3324 domain-containing protein -
HZ311_RS15115 60075..60890 - 816 WP_178946861.1 WxL domain-containing protein -
HZ311_RS15120 60907..61170 - 264 WP_178946867.1 LPXTG cell wall anchor domain-containing protein -
HZ311_RS15125 61905..63218 - 1314 Protein_52 IS4 family transposase -
HZ311_RS15130 63486..63755 - 270 WP_062806315.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZ311_RS15135 63752..63967 - 216 WP_034690365.1 translation repressor RelB Antitoxin
HZ311_RS15140 64596..64889 - 294 WP_178946862.1 hypothetical protein -
HZ311_RS15145 65315..65959 - 645 WP_178946868.1 DNA/RNA non-specific endonuclease -
HZ311_RS15150 66055..66828 - 774 WP_178946869.1 N-6 DNA methylase -
HZ311_RS15155 66870..67289 - 420 WP_178946863.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67434 67434
- flank IS/Tn - - 61779..63218 1439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

Protein of unknown function DUF6290

(1-67)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10569.30 Da        Isoelectric Point: 9.6725

>T33124 WP_062806315.1 NZ_AP019811:c63755-63486 [Enterococcus mundtii]
MKYHVEFDKRAQKEFLKLDKPIRNQILLWLNKNIEGCEDPRWTGKGLTADKSGLWRYRIGKYRLICDIHDDYALVLVVKA
GKRETIYEG

Download         Length: 270 bp

>T33124 NZ_AP019811:c63755-63486 [Enterococcus mundtii]
ATGAAGTATCACGTTGAATTTGATAAACGCGCACAAAAAGAGTTTTTGAAGTTAGATAAGCCCATTCGAAATCAAATTTT
ACTTTGGTTGAATAAGAATATAGAGGGTTGCGAAGATCCAAGGTGGACTGGAAAAGGACTCACGGCTGATAAAAGTGGGT
TGTGGCGATATCGAATAGGAAAATATAGATTAATATGTGATATTCATGATGATTATGCTTTAGTTCTTGTTGTTAAAGCA
GGCAAACGAGAAACCATTTATGAAGGCTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7886.91 Da        Isoelectric Point: 3.9488

>AT33124 WP_034690365.1 NZ_AP019811:c63967-63752 [Enterococcus mundtii]
MSITTIRLNEQEEAFFQSYAELTGQPLSTLMKQALTEKIEDYLDLQAGSEALKNLSGESVSLQDMMKAEGL

Download         Length: 216 bp

>AT33124 NZ_AP019811:c63967-63752 [Enterococcus mundtii]
ATGAGCATTACTACAATAAGGTTAAATGAGCAAGAAGAGGCATTTTTTCAAAGTTATGCTGAACTAACTGGTCAGCCATT
ATCAACGTTAATGAAACAAGCATTGACAGAAAAAATTGAAGATTACCTAGATTTGCAAGCTGGATCTGAAGCTCTGAAAA
ATTTATCTGGCGAATCTGTTTCTCTTCAAGATATGATGAAGGCTGAAGGTTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A848MZZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A022N681

References