Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4182480..4184155 Replicon chromosome
Accession NZ_AP019807
Organism Microbulbifer sp. GL-2

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag GL2_RS18135 Protein ID WP_143732133.1
Coordinates 4182857..4184155 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag GL2_RS18130 Protein ID WP_143732131.1
Coordinates 4182480..4182863 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL2_RS18110 4177525..4177956 - 432 WP_143732125.1 GFA family protein -
GL2_RS18115 4178179..4178604 - 426 WP_143732127.1 MAPEG family protein -
GL2_RS18120 4179095..4180483 - 1389 WP_143732129.1 ATP-dependent RNA helicase DbpA -
GL2_RS18125 4180924..4181805 - 882 WP_197736475.1 trypsin-like serine protease -
GL2_RS18130 4182480..4182863 + 384 WP_143732131.1 helix-turn-helix domain-containing protein Antitoxin
GL2_RS18135 4182857..4184155 + 1299 WP_143732133.1 type II toxin-antitoxin system HipA family toxin Toxin
GL2_RS18140 4184340..4185575 + 1236 WP_143732952.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-63)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48100.53 Da        Isoelectric Point: 5.8799

>T33121 WP_143732133.1 NZ_AP019807:4182857-4184155 [Microbulbifer sp. GL-2]
MVKQTNTATVHLWGQLVGAVHWDETGYGSFEYAPEFLQRGLDIAPITMPNEASVEPYIFRTLSRDTFKGLPGLLADCLPD
KFGNAVIDAWLARQGRTPESFNPIERLCYTGTRGMGALEFQPAVDGSFKDSVDLNIEELVKLAAAITHRQTDLNAQFGKS
DAERSGALLDILRVGTSAGGARAKAVIAMNDAGDIRSGQVPAPKDYDYWLLKFDGAGDLELGTTDGFGRIEYAYHLMALE
AGINMTECKLLEENGRAHFMTRRFDRMHGKKLHMQSLCGIAHLDFNMAGAHSYEQAFSVMRELYLPKSEAIQQYRRMVFN
VLARNQDDHTKNIAFLMEPEGEWSLSPAFDVTYAHNPGGAWTSQHQMSINGKRDHFQLEDLLAVGRAISIKQPMDIIEEV
AAAVKKWEGFAKTAGVSTSWMVEISQNHRQLF

Download         Length: 1299 bp

>T33121 NZ_AP019807:4182857-4184155 [Microbulbifer sp. GL-2]
ATGGTAAAGCAAACAAATACCGCCACAGTACATCTGTGGGGGCAGCTGGTTGGCGCTGTTCATTGGGATGAAACCGGGTA
TGGCTCATTTGAATACGCCCCGGAATTTCTGCAGCGCGGACTGGATATTGCCCCTATTACTATGCCCAATGAGGCTTCGG
TGGAGCCCTATATTTTCCGTACTCTCAGCCGGGACACCTTCAAGGGCTTACCGGGGCTCCTTGCGGATTGCTTACCTGAT
AAGTTCGGTAACGCCGTCATTGATGCCTGGCTCGCCCGACAGGGACGCACCCCAGAGAGCTTTAACCCTATTGAGCGCCT
CTGTTACACCGGTACGCGTGGTATGGGCGCGCTGGAGTTTCAACCTGCCGTGGATGGTAGCTTTAAGGATTCTGTCGATC
TCAATATTGAGGAGCTGGTGAAACTGGCGGCCGCGATTACCCATAGGCAAACCGATCTCAATGCCCAATTTGGTAAAAGC
GATGCAGAGAGATCAGGCGCCTTGCTGGATATCTTAAGAGTGGGAACCAGTGCCGGGGGCGCCAGAGCAAAGGCGGTAAT
CGCCATGAATGACGCGGGAGATATTCGCTCAGGCCAAGTTCCCGCACCAAAAGATTACGACTACTGGCTGCTGAAATTCG
ATGGTGCCGGGGACCTGGAGCTCGGTACTACCGACGGGTTTGGGAGAATTGAATACGCTTACCATCTTATGGCCCTGGAA
GCTGGCATTAACATGACTGAGTGCAAGCTGCTGGAAGAAAACGGCAGAGCGCACTTTATGACGCGACGCTTCGACCGAAT
GCATGGTAAGAAGCTGCACATGCAGTCCCTCTGTGGCATCGCCCACTTAGATTTCAATATGGCCGGTGCCCACTCATACG
AGCAGGCCTTTAGCGTTATGCGCGAGCTTTACCTGCCCAAAAGTGAAGCGATTCAGCAATATCGACGGATGGTATTCAAT
GTTTTGGCCAGGAATCAGGATGATCACACCAAGAACATTGCGTTCCTGATGGAACCCGAAGGCGAGTGGTCCCTTTCACC
GGCGTTCGACGTGACCTATGCCCACAATCCCGGTGGCGCATGGACCAGCCAACATCAAATGAGCATCAACGGCAAACGGG
ACCATTTCCAATTAGAGGACTTACTGGCCGTAGGAAGGGCAATCAGCATCAAGCAGCCAATGGACATCATTGAAGAGGTG
GCAGCAGCAGTGAAAAAATGGGAGGGCTTTGCCAAAACTGCTGGCGTTTCCACAAGTTGGATGGTCGAAATCAGCCAAAA
TCATCGGCAACTATTTTAA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 14171.35 Da        Isoelectric Point: 11.4638

>AT33121 WP_143732131.1 NZ_AP019807:4182480-4182863 [Microbulbifer sp. GL-2]
MTFHGQSDKQILETLGSRLREYRLRMNLTQDDMAERAGLSSSTIKGLEAGRGRLDSLVAALRVLRRLEALEAFLPAPAVS
PMQLATHGKQRKRARASNNTKTVKESSVKGTPKAQTSKIKKRDKPEW

Download         Length: 384 bp

>AT33121 NZ_AP019807:4182480-4182863 [Microbulbifer sp. GL-2]
ATGACCTTTCACGGGCAATCGGATAAGCAGATACTTGAGACACTCGGCAGCCGCCTTAGGGAGTACCGTTTGCGGATGAA
TCTCACCCAGGATGATATGGCTGAGCGAGCTGGATTGTCCTCCTCTACCATCAAGGGCTTGGAAGCTGGTCGCGGCAGGC
TCGACAGCCTGGTTGCTGCGCTGAGAGTGCTCCGCCGGCTGGAAGCTCTGGAGGCATTCCTCCCAGCTCCAGCAGTCAGC
CCCATGCAACTTGCTACCCACGGAAAGCAACGAAAAAGAGCCAGGGCTTCTAACAACACCAAGACTGTCAAAGAAAGCTC
TGTGAAAGGCACCCCCAAGGCCCAGACAAGCAAAATAAAAAAGAGAGATAAGCCAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References