33110

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 5052759..5053573 Replicon chromosome
Accession NZ_AP019803
Organism Escherichia coli strain KY 1497

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ECKY1497_RS24195 Protein ID WP_001054376.1
Coordinates 5053316..5053573 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ECKY1497_RS24190 Protein ID WP_001309181.1
Coordinates 5052759..5053304 (-) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECKY1497_RS24160 (5048450) 5048450..5049763 - 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -
ECKY1497_RS24165 (5049775) 5049775..5050053 - 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
ECKY1497_RS24170 (5050050) 5050050..5051171 - 1122 WP_000010829.1 M42 family metallopeptidase -
ECKY1497_RS24175 (5051416) 5051416..5051532 - 117 Protein_4725 VOC family protein -
ECKY1497_RS24180 (5051570) 5051570..5051788 - 219 Protein_4726 hypothetical protein -
ECKY1497_RS24185 (5051957) 5051957..5052703 - 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ECKY1497_RS24190 (5052759) 5052759..5053304 - 546 WP_001309181.1 N-acetyltransferase Antitoxin
ECKY1497_RS24195 (5053316) 5053316..5053573 - 258 WP_001054376.1 YjhX family toxin Toxin
ECKY1497_RS24200 (5054064) 5054064..5054195 - 132 WP_001309182.1 hypothetical protein -
ECKY1497_RS24205 (5054311) 5054311..5055551 + 1241 Protein_4731 helicase YjhR -
ECKY1497_RS24210 (5055819) 5055819..5056024 - 206 Protein_4732 HNH endonuclease -
ECKY1497_RS24215 (5056134) 5056134..5057114 - 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ECKY1497_RS24220 (5057179) 5057179..5058285 - 1107 WP_001309184.1 N-acetylneuraminate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T33110 WP_001054376.1 NZ_AP019803:c5053573-5053316 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T33110 NZ_AP019803:c5053573-5053316 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT33110 WP_001309181.1 NZ_AP019803:c5053304-5052759 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT33110 NZ_AP019803:c5053304-5052759 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References