Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3449041..3449875 Replicon chromosome
Accession NZ_AP019803
Organism Escherichia coli strain KY 1497

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag ECKY1497_RS16550 Protein ID WP_000854689.1
Coordinates 3449498..3449875 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag ECKY1497_RS16545 Protein ID WP_001285599.1
Coordinates 3449041..3449421 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECKY1497_RS16510 (3445128) 3445128..3445583 + 456 WP_001309747.1 IrmA family protein -
ECKY1497_RS16515 (3445726) 3445726..3445815 + 90 WP_225385657.1 DUF905 family protein -
ECKY1497_RS16520 (3445994) 3445994..3446815 + 822 WP_099004483.1 DUF932 domain-containing protein -
ECKY1497_RS16525 (3447079) 3447079..3447552 + 474 WP_023351915.1 antirestriction protein -
ECKY1497_RS16530 (3447568) 3447568..3448044 + 477 WP_001186761.1 RadC family protein -
ECKY1497_RS16535 (3448107) 3448107..3448328 + 222 WP_000692315.1 DUF987 domain-containing protein -
ECKY1497_RS16540 (3448347) 3448347..3448991 + 645 WP_000086757.1 hypothetical protein -
ECKY1497_RS16545 (3449041) 3449041..3449421 + 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECKY1497_RS16550 (3449498) 3449498..3449875 + 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
ECKY1497_RS16555 (3449872) 3449872..3450360 + 489 WP_000761698.1 DUF5983 family protein -
ECKY1497_RS16560 (3450377) 3450377..3450574 + 198 WP_000839250.1 DUF957 domain-containing protein -
ECKY1497_RS16565 (3450659) 3450659..3451504 + 846 WP_001446750.1 DUF4942 domain-containing protein -
ECKY1497_RS16570 (3451573) 3451573..3451968 + 396 WP_000208382.1 DUF6088 family protein -
ECKY1497_RS16575 (3451961) 3451961..3452894 + 934 Protein_3250 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
ECKY1497_RS16580 (3453311) 3453311..3453481 + 171 Protein_3251 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3453326..3453481 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T33102 WP_000854689.1 NZ_AP019803:3449498-3449875 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T33102 NZ_AP019803:3449498-3449875 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT33102 WP_001285599.1 NZ_AP019803:3449041-3449421 [Escherichia coli]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT33102 NZ_AP019803:3449041-3449421 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGTTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References