Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1601056..1601582 Replicon chromosome
Accession NZ_AP019803
Organism Escherichia coli strain KY 1497

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag ECKY1497_RS07580 Protein ID WP_000323025.1
Coordinates 1601295..1601582 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag ECKY1497_RS07575 Protein ID WP_000534858.1
Coordinates 1601056..1601295 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECKY1497_RS07545 (1596318) 1596318..1596932 + 615 WP_001265627.1 hypothetical protein -
ECKY1497_RS07550 (1596935) 1596935..1597957 + 1023 WP_000915483.1 DUF4868 domain-containing protein -
ECKY1497_RS07555 (1598462) 1598462..1599532 + 1071 Protein_1473 ISNCY family transposase -
ECKY1497_RS07560 (1599605) 1599605..1599754 + 150 WP_011443592.1 protein YdfW -
ECKY1497_RS07565 (1600191) 1600191..1600523 - 333 WP_001301033.1 FlxA-like family protein -
ECKY1497_RS07570 (1600726) 1600726..1601031 - 306 WP_001326990.1 protein YdfV -
ECKY1497_RS07575 (1601056) 1601056..1601295 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
ECKY1497_RS07580 (1601295) 1601295..1601582 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
ECKY1497_RS07585 (1601654) 1601654..1601809 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
ECKY1497_RS07590 (1602026) 1602026..1602277 + 252 WP_000980994.1 protein Rem -
ECKY1497_RS07595 (1602344) 1602344..1602622 + 279 WP_012304870.1 hypothetical protein -
ECKY1497_RS07600 (1602624) 1602624..1603673 + 1050 WP_001265199.1 DUF968 domain-containing protein -
ECKY1497_RS07605 (1603687) 1603687..1604091 + 405 Protein_1483 antitermination protein -
ECKY1497_RS07610 (1604148) 1604148..1604845 + 698 WP_151884388.1 IS1 family transposase -
ECKY1497_RS07615 (1604838) 1604838..1605014 + 177 WP_138069336.1 cold-shock protein -
ECKY1497_RS07620 (1605017) 1605017..1605082 + 66 WP_120795388.1 small protein YnfR -
ECKY1497_RS07625 (1605087) 1605087..1605317 + 231 WP_000720962.1 protein YnfN -
ECKY1497_RS07630 (1605489) 1605489..1605662 + 174 WP_001019606.1 addiction module toxin, GnsA/GnsB family -
ECKY1497_RS07635 (1605814) 1605814..1606224 - 411 WP_000373090.1 DUF1398 domain-containing protein -
ECKY1497_RS07640 (1606282) 1606282..1606515 - 234 WP_001368374.1 YlcI/YnfO family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1572206..1630105 57899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T33095 WP_000323025.1 NZ_AP019803:1601295-1601582 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T33095 NZ_AP019803:1601295-1601582 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT33095 WP_000534858.1 NZ_AP019803:1601056-1601295 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT33095 NZ_AP019803:1601056-1601295 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References