Detailed information of TA system TA033076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/YefM(antitoxin)
• Location: 2630105..2630667
• Replicon: chromosome
• Accession: NZ_AP019798
• Organism: Vibrio rotiferianus strain AM7

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: VroAM7_RS12345
• Protein ID: WP_143692864.1
• Coordinates: 2630365..2630667 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: VroAM7_RS12340
• Protein ID: WP_143692863.1
• Coordinates: 2630105..2630368 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VroAM7_RS12315	2625151..2626125	-	975	WP_143692861.1	TDT family transporter	-
VroAM7_RS12320	2626237..2627154	+	918	WP_143692862.1	LysR family transcriptional regulator	-
VroAM7_RS12325	2627301..2627600	+	300	WP_005380208.1	YebG family protein	-
VroAM7_RS12330	2628092..2628784	+	693	WP_005427365.1	iron-sulfur cluster assembly scaffold protein	-
VroAM7_RS12335	2628808..2629791	+	984	WP_005427312.1	GGGtGRT protein	-
VroAM7_RS12340	2630105..2630368	+	264	WP_143692863.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VroAM7_RS12345	2630365..2630667	+	303	WP_143692864.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VroAM7_RS12355	2631088..2632119	+	1032	WP_005391708.1	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-
VroAM7_RS12360	2632277..2633332	-	1056	WP_038885180.1	glycerophosphodiester phosphodiesterase	-
VroAM7_RS12365	2633387..2634754	-	1368	WP_010449918.1	glycerol-3-phosphate transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11552.38 Da
• Isoelectric Point: 9.3747

>T33076 WP_143692864.1 NZ_AP019798:2630365-2630667 [Vibrio rotiferianus]
MTQYKLSPAAQTDLIDIRRYTLENWGGAQWTNYFGELKQSMALLASNELIGIDMPELGTSYCRFPLKHHVIYYIRKPDHI
VIAAVLGRNMSPAKHFQRQL

Nucleotide

• Length: 303 bp

>T33076 NZ_AP019798:2630365-2630667 [Vibrio rotiferianus]
ATGACACAATACAAACTTTCTCCCGCAGCCCAAACGGACCTTATCGACATTCGCCGTTATACGCTTGAAAATTGGGGAGG
CGCACAGTGGACCAATTATTTCGGAGAGCTAAAACAATCAATGGCGTTATTAGCTAGCAATGAGTTGATTGGCATTGACA
TGCCGGAACTAGGAACTAGTTACTGCCGCTTTCCGTTAAAGCATCATGTAATTTATTACATCAGGAAACCGGATCATATT
GTTATTGCAGCAGTCCTAGGGCGTAACATGTCTCCGGCTAAGCACTTTCAGCGACAGTTATAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9723.04 Da
• Isoelectric Point: 4.2075

>AT33076 WP_143692863.1 NZ_AP019798:2630105-2630368 [Vibrio rotiferianus]
MQSLTANTAKTKFGDLLMKVQREPVQISKNGSPVAVIMSCEEYEELEALKMAMVKSRFEQAERDIVNGDLVDGESFMSEL
DSGKFDE

Nucleotide

• Length: 264 bp

>AT33076 NZ_AP019798:2630105-2630368 [Vibrio rotiferianus]
ATGCAATCATTAACCGCAAACACTGCAAAAACTAAATTTGGTGACTTACTGATGAAAGTACAGCGAGAGCCAGTACAAAT
CAGTAAAAATGGTTCACCTGTGGCAGTTATTATGTCATGTGAAGAATACGAGGAACTTGAAGCCTTGAAGATGGCGATGG
TGAAATCACGTTTTGAACAAGCGGAACGCGACATCGTGAATGGAGATTTAGTGGATGGCGAAAGCTTCATGAGCGAACTA
GATTCAGGCAAGTTTGACGAATGA