Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 1930903..1931431 | Replicon | chromosome |
| Accession | NZ_AP019798 | ||
| Organism | Vibrio rotiferianus strain AM7 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | K5TRR0 |
| Locus tag | VroAM7_RS09000 | Protein ID | WP_005377002.1 |
| Coordinates | 1931141..1931431 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR02 |
| Locus tag | VroAM7_RS08995 | Protein ID | WP_005377003.1 |
| Coordinates | 1930903..1931151 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VroAM7_RS08935 | 1926147..1926239 | - | 93 | WP_074190183.1 | DUF3265 domain-containing protein | - |
| VroAM7_RS08940 | 1926254..1926871 | - | 618 | WP_143692578.1 | YdcF family protein | - |
| VroAM7_RS08950 | 1926967..1927713 | - | 747 | WP_143692579.1 | hypothetical protein | - |
| VroAM7_RS08955 | 1927886..1928443 | - | 558 | WP_143692580.1 | nucleotidyltransferase family protein | - |
| VroAM7_RS08960 | 1928464..1928586 | - | 123 | WP_080772513.1 | DUF3265 domain-containing protein | - |
| VroAM7_RS08965 | 1928571..1928855 | - | 285 | WP_143692581.1 | hypothetical protein | - |
| VroAM7_RS27280 | 1929063..1929332 | - | 270 | WP_197737452.1 | hypothetical protein | - |
| VroAM7_RS08975 | 1929364..1929456 | - | 93 | WP_194842422.1 | DUF3265 domain-containing protein | - |
| VroAM7_RS08980 | 1929471..1929959 | - | 489 | WP_071236582.1 | GNAT family N-acetyltransferase | - |
| VroAM7_RS08990 | 1930127..1930708 | - | 582 | WP_143692582.1 | hypothetical protein | - |
| VroAM7_RS27285 | 1930760..1930828 | - | 69 | WP_074531725.1 | DUF3265 domain-containing protein | - |
| VroAM7_RS08995 | 1930903..1931151 | + | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| VroAM7_RS09000 | 1931141..1931431 | + | 291 | WP_005377002.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VroAM7_RS27290 | 1931450..1931539 | - | 90 | WP_074181679.1 | DUF3265 domain-containing protein | - |
| VroAM7_RS09010 | 1931557..1932297 | - | 741 | WP_143692583.1 | hypothetical protein | - |
| VroAM7_RS09015 | 1932328..1932420 | - | 93 | WP_143692584.1 | DUF3265 domain-containing protein | - |
| VroAM7_RS09020 | 1932435..1932998 | - | 564 | WP_143692585.1 | hypothetical protein | - |
| VroAM7_RS09025 | 1933146..1933592 | - | 447 | WP_143692586.1 | hypothetical protein | - |
| VroAM7_RS09030 | 1933594..1933899 | - | 306 | WP_143692587.1 | DUF4325 domain-containing protein | - |
| VroAM7_RS09035 | 1933896..1934459 | - | 564 | WP_143692588.1 | hypothetical protein | - |
| VroAM7_RS09040 | 1934623..1935126 | - | 504 | WP_143692589.1 | peptide deformylase | - |
| VroAM7_RS09045 | 1935164..1935256 | - | 93 | WP_005445734.1 | DUF3265 domain-containing protein | - |
| VroAM7_RS09050 | 1935288..1935716 | - | 429 | WP_053397211.1 | GNAT family N-acetyltransferase | - |
| VroAM7_RS09055 | 1935752..1935844 | - | 93 | WP_197737453.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | VP1611 | 1711712..2127777 | 416065 | |
| - | inside | Integron | - | - | 1889467..1947985 | 58518 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11261.25 Da Isoelectric Point: 10.5932
>T33074 WP_005377002.1 NZ_AP019798:1931141-1931431 [Vibrio rotiferianus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD
Download Length: 291 bp
>T33074 NZ_AP019798:1931141-1931431 [Vibrio rotiferianus]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCAGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCAGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9079.37 Da Isoelectric Point: 3.9610
>AT33074 WP_005377003.1 NZ_AP019798:1930903-1931151 [Vibrio rotiferianus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT33074 NZ_AP019798:1930903-1931151 [Vibrio rotiferianus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR03 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR02 |