Detailed information of TA system TA033071

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1911511..1912070
• Replicon: chromosome
• Accession: NZ_AP019798
• Organism: Vibrio rotiferianus strain AM7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: VroAM7_RS08760
• Protein ID: WP_143692564.1
• Coordinates: 1911792..1912070 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: VroAM7_RS08755
• Protein ID: WP_005398409.1
• Coordinates: 1911511..1911795 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VroAM7_RS08690	1907300..1907392	-	93	WP_193343211.1	DUF3265 domain-containing protein	-
VroAM7_RS08695	1907413..1907976	-	564	WP_143692559.1	hypothetical protein	-
VroAM7_RS08700	1908003..1908092	-	90	WP_143693213.1	DUF3265 domain-containing protein	-
VroAM7_RS08710	1908741..1909043	-	303	WP_143692561.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VroAM7_RS08715	1909031..1909288	-	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
VroAM7_RS08720	1909370..1909459	-	90	WP_072609597.1	DUF3265 domain-containing protein	-
VroAM7_RS08725	1909573..1909815	+	243	WP_005442033.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
VroAM7_RS08730	1909823..1910122	+	300	WP_015296889.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VroAM7_RS08735	1910301..1910681	-	381	WP_143692562.1	STAS/SEC14 domain-containing protein	-
VroAM7_RS08750	1911303..1911434	-	132	WP_143692563.1	DUF3265 domain-containing protein	-
VroAM7_RS08755	1911511..1911795	+	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
VroAM7_RS08760	1911792..1912070	+	279	WP_143692564.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VroAM7_RS08765	1912227..1912595	-	369	WP_143692565.1	VOC family protein	-
VroAM7_RS08770	1912643..1912735	-	93	WP_079400283.1	DUF3265 domain-containing protein	-
VroAM7_RS08775	1912849..1913817	+	969	WP_143692547.1	IS30-like element ISVa6 family transposase	-
VroAM7_RS08780	1913854..1914624	-	771	WP_172622550.1	FRG domain-containing protein	-
VroAM7_RS08785	1914664..1914789	-	126	WP_143693220.1	DUF3265 domain-containing protein	-
VroAM7_RS08790	1914786..1915157	-	372	WP_143692567.1	hypothetical protein	-
VroAM7_RS08795	1915241..1915363	-	123	WP_143692568.1	DUF3265 domain-containing protein	-
VroAM7_RS08800	1915360..1915644	-	285	WP_143692569.1	hypothetical protein	-
VroAM7_RS08805	1915646..1915957	-	312	WP_143692570.1	hypothetical protein	-
VroAM7_RS08810	1915984..1916076	-	93	WP_079858411.1	DUF3265 domain-containing protein	-
VroAM7_RS08815	1916091..1916432	-	342	WP_172622548.1	hypothetical protein	-
VroAM7_RS08825	1916663..1916935	+	273	WP_143692571.1	DUF1778 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	VP1611	1711712..2127777	416065
	-	flank	IS/Tn	-	-	1913041..1913817	776
	-	inside	Integron	-	-	1889467..1947985	58518

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10925.59 Da
• Isoelectric Point: 4.3430

>T33071 WP_143692564.1 NZ_AP019798:1911792-1912070 [Vibrio rotiferianus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPFMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T33071 NZ_AP019798:1911792-1912070 [Vibrio rotiferianus]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTTATGGGCGTACAACGAGATGGCA
TCCGCGGACGATTGCTTATTATTCCTGAGATTTCGATGATTGTGTCTTACTGGGTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT33071 WP_005398409.1 NZ_AP019798:1911511-1911795 [Vibrio rotiferianus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT33071 NZ_AP019798:1911511-1911795 [Vibrio rotiferianus]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A347UR21