Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1905311..1905876 Replicon chromosome
Accession NZ_AP019798
Organism Vibrio rotiferianus strain AM7

Toxin (Protein)


Gene name relE Uniprot ID A0A0H2MSY5
Locus tag VroAM7_RS08675 Protein ID WP_015296903.1
Coordinates 1905311..1905598 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3BLE1
Locus tag VroAM7_RS08680 Protein ID WP_000086647.1
Coordinates 1905595..1905876 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VroAM7_RS08635 1900593..1901246 - 654 WP_172622549.1 hypothetical protein -
VroAM7_RS27265 1901210..1901302 - 93 WP_006074995.1 DUF3265 domain-containing protein -
VroAM7_RS08645 1901323..1901808 - 486 WP_010448891.1 lecithin retinol acyltransferase family protein -
VroAM7_RS08650 1902025..1902420 - 396 WP_143692555.1 DUF3465 domain-containing protein -
VroAM7_RS08655 1902559..1903143 - 585 WP_143692556.1 hypothetical protein -
VroAM7_RS27270 1903181..1903273 - 93 WP_197737456.1 DUF3265 domain-containing protein -
VroAM7_RS08665 1903387..1904351 + 965 Protein_1623 IS30 family transposase -
VroAM7_RS27135 1905191..1905283 - 93 WP_017790380.1 DUF3265 domain-containing protein -
VroAM7_RS08675 1905311..1905598 - 288 WP_015296903.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VroAM7_RS08680 1905595..1905876 - 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VroAM7_RS08685 1906053..1907267 - 1215 WP_143692558.1 DUF3644 domain-containing protein -
VroAM7_RS08690 1907300..1907392 - 93 WP_193343211.1 DUF3265 domain-containing protein -
VroAM7_RS08695 1907413..1907976 - 564 WP_143692559.1 hypothetical protein -
VroAM7_RS08700 1908003..1908092 - 90 WP_143693213.1 DUF3265 domain-containing protein -
VroAM7_RS08710 1908741..1909043 - 303 WP_143692561.1 type II toxin-antitoxin system RelE/ParE family toxin -
VroAM7_RS08715 1909031..1909288 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VroAM7_RS08720 1909370..1909459 - 90 WP_072609597.1 DUF3265 domain-containing protein -
VroAM7_RS08725 1909573..1909815 + 243 WP_005442033.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VroAM7_RS08730 1909823..1910122 + 300 WP_015296889.1 type II toxin-antitoxin system RelE/ParE family toxin -
VroAM7_RS08735 1910301..1910681 - 381 WP_143692562.1 STAS/SEC14 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1711712..2127777 416065
- inside Integron - - 1889467..1947985 58518


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11003.69 Da        Isoelectric Point: 5.1098

>T33068 WP_015296903.1 NZ_AP019798:c1905598-1905311 [Vibrio rotiferianus]
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Download         Length: 288 bp

>T33068 NZ_AP019798:c1905598-1905311 [Vibrio rotiferianus]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
GGCAGAGAAGTGGGTAAACGAAGTTTTTGATAAAACTGAACTCCTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCATACGAATTATCGTGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATTCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10398.91 Da        Isoelectric Point: 5.8650

>AT33068 WP_000086647.1 NZ_AP019798:c1905876-1905595 [Vibrio rotiferianus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Download         Length: 282 bp

>AT33068 NZ_AP019798:c1905876-1905595 [Vibrio rotiferianus]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTATCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACGCAACGTGGCAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2MSY5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G0X0

References