Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1894572..1895338 Replicon chromosome
Accession NZ_AP019798
Organism Vibrio rotiferianus strain AM7

Toxin (Protein)


Gene name - Uniprot ID A0A432DAA5
Locus tag VroAM7_RS08575 Protein ID WP_017053840.1
Coordinates 1894841..1895338 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A347UQX1
Locus tag VroAM7_RS08570 Protein ID WP_017420534.1
Coordinates 1894572..1894844 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VroAM7_RS08520 1890096..1890566 - 471 WP_143693201.1 GNAT family N-acetyltransferase -
VroAM7_RS08525 1890708..1891094 - 387 WP_143692544.1 NUDIX hydrolase -
VroAM7_RS08530 1891135..1891227 - 93 WP_197737450.1 DUF3265 domain-containing protein -
VroAM7_RS08540 1891799..1892356 - 558 WP_143692545.1 nucleotidyltransferase family protein -
VroAM7_RS08545 1892381..1892473 - 93 WP_140112330.1 DUF3265 domain-containing protein -
VroAM7_RS08550 1892499..1892960 - 462 WP_143692546.1 hypothetical protein -
VroAM7_RS08555 1892974..1893249 - 276 WP_023623398.1 hypothetical protein -
VroAM7_RS08560 1893277..1893369 - 93 WP_071652217.1 DUF3265 domain-containing protein -
VroAM7_RS08565 1893483..1894451 + 969 WP_143692547.1 IS30-like element ISVa6 family transposase -
VroAM7_RS08570 1894572..1894844 + 273 WP_017420534.1 DUF1778 domain-containing protein Antitoxin
VroAM7_RS08575 1894841..1895338 + 498 WP_017053840.1 GNAT family N-acetyltransferase Toxin
VroAM7_RS08580 1895495..1895944 - 450 WP_143692548.1 hypothetical protein -
VroAM7_RS08585 1896015..1896107 - 93 WP_079858411.1 DUF3265 domain-containing protein -
VroAM7_RS08590 1896122..1896463 - 342 WP_172622548.1 hypothetical protein -
VroAM7_RS08595 1896617..1896883 - 267 WP_017188766.1 hypothetical protein -
VroAM7_RS08600 1897114..1897731 - 618 WP_143692551.1 HAD family phosphatase -
VroAM7_RS08605 1897887..1898210 - 324 WP_143692552.1 hypothetical protein -
VroAM7_RS08610 1898342..1898971 - 630 WP_038938930.1 DUF1349 domain-containing protein -
VroAM7_RS08615 1898949..1899149 - 201 WP_143693209.1 DUF3265 domain-containing protein -
VroAM7_RS08620 1899162..1899347 - 186 WP_138942408.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 1711712..2127777 416065
- flank IS/Tn - - 1893675..1894451 776
- inside Integron - - 1889467..1947985 58518


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18458.12 Da        Isoelectric Point: 8.8085

>T33067 WP_017053840.1 NZ_AP019798:1894841-1895338 [Vibrio rotiferianus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T33067 NZ_AP019798:1894841-1895338 [Vibrio rotiferianus]
ATGATGAATACGGTACTTCTAGACAAAGCTAAACACGATAGAAACCGATTCAACTGTGGCATCGAAGCTCTCAATAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCAAAGAAGGACAACACCAGAACGTTTGTTTTGGAAGATGATAGCGACAACTCAC
ATGTTATCGGCTTTTACACGCTAACAATGACACCAATTGATTTAAAGGCATTGCCTGATAAGTTACAAAAAAAGCACCAA
TCATCCACCTCTGGTGGTCTGATTGCCCGCCTTGCTGTCGATGACCGATACAAAGGGAAAGGATTTGGTGAGTGGTTGCT
TATCGACGCACTCAGAAAGCTATTAGCCGCTAGTGATAGCGTTGCATTTCCAGTTGTTATCGTTGATGCCAAAGACGGAG
CAAAACATTTCTATGAACGCTATGGTTTTCAAGCATTTCAAGACGCTGAAAACAAACTCTTCATCACCATTGCAGATGTG
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9735.22 Da        Isoelectric Point: 8.5960

>AT33067 WP_017420534.1 NZ_AP019798:1894572-1894844 [Vibrio rotiferianus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Download         Length: 273 bp

>AT33067 NZ_AP019798:1894572-1894844 [Vibrio rotiferianus]
ATGGCTACTACTTTGCCGCGCATCACCGCTAGAGTTGATGTCGATACACAAGACTTACTTACTAAGGCTGCCGCGATCGC
CGGCATGTCTAGTATCAACTCGTTTGTTCTAAGCGCTGCAATCGAAAAAGCTAAACAAGTCATCGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCAGATGCGATGTTGCTCATGGAAGCTTTAGATCGTCCTGCAACACAGAACTCAAAACTAAAAGCC
GCTGCTGATCGATACGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A432DAA5

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQX1

References