Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2443801..2444438 Replicon chromosome
Accession NZ_AP019791
Organism Rubrobacter xylanophilus strain AA3-22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RxyAA322_RS12465 Protein ID WP_143528621.1
Coordinates 2444022..2444438 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RxyAA322_RS12460 Protein ID WP_143528620.1
Coordinates 2443801..2444022 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RxyAA322_RS12440 2439089..2440075 + 987 WP_143528616.1 sulfotransferase domain-containing protein -
RxyAA322_RS12445 2440190..2441110 + 921 WP_172620841.1 sulfotransferase -
RxyAA322_RS12450 2441233..2442588 + 1356 WP_143528618.1 sulfotransferase -
RxyAA322_RS12455 2442699..2443751 + 1053 WP_143528619.1 glycosyltransferase family 2 protein -
RxyAA322_RS12460 2443801..2444022 + 222 WP_143528620.1 ribbon-helix-helix domain-containing protein Antitoxin
RxyAA322_RS12465 2444022..2444438 + 417 WP_143528621.1 PIN domain-containing protein Toxin
RxyAA322_RS12470 2444552..2445673 + 1122 WP_143528622.1 sulfotransferase -
RxyAA322_RS12475 2445670..2447031 + 1362 WP_172620842.1 glycosyltransferase family 4 protein -
RxyAA322_RS12480 2447033..2447890 + 858 WP_143528624.1 dTDP-4-dehydrorhamnose reductase -
RxyAA322_RS12485 2447887..2449062 + 1176 WP_143528625.1 sulfotransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-38)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15172.22 Da        Isoelectric Point: 5.2291

>T33060 WP_143528621.1 NZ_AP019791:2444022-2444438 [Rubrobacter xylanophilus]
MILDTSGLLAAIDSDQRSHAAARRAIEADGGPFILSPFVLAELDYLLATRVGRGAQLALLDEVGRGAYRLERFTATDVAR
ATEVLRRYEDLDLGLTDASNVVLSRRHGVSDILTLDERHFRVLSAAENRPFRLLPADL

Download         Length: 417 bp

>T33060 NZ_AP019791:2444022-2444438 [Rubrobacter xylanophilus]
ATGATCCTGGACACCAGCGGGCTGCTGGCGGCCATCGACTCGGACCAGCGCTCGCACGCCGCCGCGAGAAGGGCGATCGA
GGCGGACGGGGGGCCGTTCATCCTCTCGCCGTTCGTGCTCGCGGAGCTGGACTACCTTCTCGCCACCCGGGTGGGAAGAG
GGGCGCAACTCGCGTTGCTCGACGAGGTCGGGCGCGGAGCCTACCGCCTCGAGCGGTTCACGGCCACGGACGTGGCGCGG
GCCACGGAGGTGCTGAGGAGGTACGAAGACCTCGACCTCGGTCTCACGGACGCGTCGAACGTGGTGCTCTCCCGCCGCCA
CGGCGTCTCCGACATCCTCACCCTCGACGAGCGGCACTTCCGGGTGCTCTCCGCCGCGGAGAACCGGCCGTTCCGGCTGC
TGCCCGCCGATCTGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8200.28 Da        Isoelectric Point: 6.3494

>AT33060 WP_143528620.1 NZ_AP019791:2443801-2444022 [Rubrobacter xylanophilus]
MKKTTVYLPDDLKRALERASEISGRSEAELIREAVRNLTSGFEPPRPRLPLFSSGDPTLAERVDRELAGFGER

Download         Length: 222 bp

>AT33060 NZ_AP019791:2443801-2444022 [Rubrobacter xylanophilus]
ATGAAGAAGACCACGGTTTATCTGCCGGATGATCTCAAGAGAGCGCTGGAACGGGCTTCGGAGATCTCCGGGCGCAGTGA
GGCGGAGCTGATCCGGGAGGCGGTGCGGAACCTGACGAGCGGGTTCGAGCCTCCACGGCCGAGGCTGCCGTTGTTCTCCA
GCGGGGATCCCACGCTGGCCGAGAGGGTGGATCGGGAGCTGGCCGGCTTCGGCGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References