Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/AbrB-PIN |
| Location | 633175..633808 | Replicon | chromosome |
| Accession | NC_008752 | ||
| Organism | Acidovorax citrulli AAC00-1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | A1TJP6 |
| Locus tag | Aave_0580 | Protein ID | WP_011793755.1 |
| Coordinates | 633395..633808 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A6B0DRJ9 |
| Locus tag | Aave_0579 | Protein ID | WP_041827216.1 |
| Coordinates | 633175..633408 (+) | Length | 78 a.a. |
Genomic Context
Location: 633175..633408 (234 bp)
Type: Antitoxin
Protein ID: WP_041827216.1
Type: Antitoxin
Protein ID: WP_041827216.1
Location: 633395..633808 (414 bp)
Type: Toxin
Protein ID: WP_011793755.1
Type: Toxin
Protein ID: WP_011793755.1
Location: 633829..634191 (363 bp)
Type: Others
Protein ID: WP_011793756.1
Type: Others
Protein ID: WP_011793756.1
Location: 636404..636976 (573 bp)
Type: Others
Protein ID: WP_011793758.1
Type: Others
Protein ID: WP_011793758.1
Location: 637048..637731 (684 bp)
Type: Others
Protein ID: WP_011793759.1
Type: Others
Protein ID: WP_011793759.1
Location: 637764..638801 (1038 bp)
Type: Others
Protein ID: WP_011793760.1
Type: Others
Protein ID: WP_011793760.1
Location: 634205..635719 (1515 bp)
Type: Others
Protein ID: WP_011793757.1
Type: Others
Protein ID: WP_011793757.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AAVE_RS02870 (Aave_0579) | 633175..633408 | + | 234 | WP_041827216.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| AAVE_RS02875 (Aave_0580) | 633395..633808 | + | 414 | WP_011793755.1 | PIN domain-containing protein | Toxin |
| AAVE_RS02880 (Aave_0581) | 633829..634191 | + | 363 | WP_011793756.1 | DUF3742 family protein | - |
| AAVE_RS02885 (Aave_0582) | 634205..635719 | - | 1515 | WP_011793757.1 | conjugal transfer protein TraG N-terminal domain-containing protein | - |
| AAVE_RS02890 (Aave_0583) | 636404..636976 | + | 573 | WP_011793758.1 | aminodeoxychorismate/anthranilate synthase component II | - |
| AAVE_RS02895 (Aave_0584) | 637048..637731 | + | 684 | WP_011793759.1 | LysE family translocator | - |
| AAVE_RS02900 (Aave_0585) | 637764..638801 | + | 1038 | WP_011793760.1 | anthranilate phosphoribosyltransferase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 422185..675592 | 253407 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 15147.48 Da Isoelectric Point: 6.2136
>T3306 WP_011793755.1 NC_008752:633395-633808 [Acidovorax citrulli AAC00-1]
MAAGKGKVFLDSNVVLYLLSEDAAKADSAEALLHRRPVISVQVLNEVTHVCVRKLKMGWGEVGQFLALVREFCSIVPLTV
EVHDRARQLAERHQLSFYDACIVAAAAAEGCQTLYSEDMHHGLIIEESLSIRNPFNV
MAAGKGKVFLDSNVVLYLLSEDAAKADSAEALLHRRPVISVQVLNEVTHVCVRKLKMGWGEVGQFLALVREFCSIVPLTV
EVHDRARQLAERHQLSFYDACIVAAAAAEGCQTLYSEDMHHGLIIEESLSIRNPFNV
Download Length: 414 bp
>T3306 NC_008752:633395-633808 [Acidovorax citrulli AAC00-1]
ATGGCCGCGGGTAAGGGCAAGGTGTTCCTCGACAGCAACGTGGTGCTCTACCTGCTGTCCGAGGACGCGGCGAAGGCGGA
CAGCGCCGAGGCGCTGCTGCATCGTCGCCCGGTCATCAGCGTCCAGGTACTCAACGAGGTCACCCACGTCTGCGTGCGCA
AGCTGAAGATGGGGTGGGGAGAGGTGGGTCAGTTCCTGGCGCTGGTGAGAGAGTTCTGCAGCATTGTTCCGCTCACAGTC
GAGGTGCACGACCGGGCCCGCCAACTGGCCGAGCGGCACCAGCTGTCGTTCTACGACGCATGCATTGTGGCGGCCGCCGC
AGCCGAAGGCTGCCAGACGCTCTACTCCGAAGACATGCACCATGGCCTCATCATCGAAGAGAGCCTGTCGATTCGTAACC
CGTTCAACGTTTGA
ATGGCCGCGGGTAAGGGCAAGGTGTTCCTCGACAGCAACGTGGTGCTCTACCTGCTGTCCGAGGACGCGGCGAAGGCGGA
CAGCGCCGAGGCGCTGCTGCATCGTCGCCCGGTCATCAGCGTCCAGGTACTCAACGAGGTCACCCACGTCTGCGTGCGCA
AGCTGAAGATGGGGTGGGGAGAGGTGGGTCAGTTCCTGGCGCTGGTGAGAGAGTTCTGCAGCATTGTTCCGCTCACAGTC
GAGGTGCACGACCGGGCCCGCCAACTGGCCGAGCGGCACCAGCTGTCGTTCTACGACGCATGCATTGTGGCGGCCGCCGC
AGCCGAAGGCTGCCAGACGCTCTACTCCGAAGACATGCACCATGGCCTCATCATCGAAGAGAGCCTGTCGATTCGTAACC
CGTTCAACGTTTGA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8518.76 Da Isoelectric Point: 8.7857
>AT3306 WP_041827216.1 NC_008752:633175-633408 [Acidovorax citrulli AAC00-1]
MLVAKWGNSLAVRLPANVVEALELREGDDIEIFVGDARSFAVSKKPGAEAMLERLRTFRGKLPADFKFNRDEANGRG
MLVAKWGNSLAVRLPANVVEALELREGDDIEIFVGDARSFAVSKKPGAEAMLERLRTFRGKLPADFKFNRDEANGRG
Download Length: 234 bp
>AT3306 NC_008752:633175-633408 [Acidovorax citrulli AAC00-1]
ATGCTAGTCGCGAAGTGGGGCAATAGCTTGGCGGTTCGCCTGCCGGCGAACGTAGTCGAAGCGCTCGAACTGCGGGAAGG
CGATGACATCGAAATCTTCGTCGGTGATGCGCGATCGTTCGCGGTGAGCAAGAAGCCCGGCGCCGAGGCGATGCTGGAGC
GCCTCCGTACCTTCCGCGGCAAGCTGCCGGCGGACTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA
ATGCTAGTCGCGAAGTGGGGCAATAGCTTGGCGGTTCGCCTGCCGGCGAACGTAGTCGAAGCGCTCGAACTGCGGGAAGG
CGATGACATCGAAATCTTCGTCGGTGATGCGCGATCGTTCGCGGTGAGCAAGAAGCCCGGCGCCGAGGCGATGCTGGAGC
GCCTCCGTACCTTCCGCGGCAAGCTGCCGGCGGACTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA
Structures
Toxin
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Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A1TJP6 |
Antitoxin
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Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6B0DRJ9 |
References
(1) Reut Shavit et al. (2015) The vapB-vapC Operon of Acidovorax citrulli Functions as a Bona-fide Toxin-Antitoxin Module. Frontiers in Microbiology 6:1499. [PubMed:26779154]