Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2948688..2949352 Replicon chromosome
Accession NZ_AP019783
Organism Methylomagnum ishizawai strain RS11D-Pr

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K5658_RS13395 Protein ID WP_221063630.1
Coordinates 2948688..2949116 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K5658_RS13400 Protein ID WP_221063631.1
Coordinates 2949116..2949352 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5658_RS13370 (MishRS11D_26460) 2944398..2945435 - 1038 WP_221063626.1 RNA 3'-terminal phosphate cyclase -
K5658_RS13375 (MishRS11D_26470) 2945537..2946478 + 942 WP_221063627.1 DUF1152 domain-containing protein -
K5658_RS13380 (MishRS11D_26480) 2946489..2947709 - 1221 WP_221063628.1 RtcB family protein -
K5658_RS13390 (MishRS11D_26490) 2947847..2948596 - 750 WP_221063629.1 hypothetical protein -
K5658_RS13395 (MishRS11D_26500) 2948688..2949116 - 429 WP_221063630.1 type II toxin-antitoxin system VapC family toxin Toxin
K5658_RS13400 (MishRS11D_26510) 2949116..2949352 - 237 WP_221063631.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K5658_RS13405 (MishRS11D_26520) 2949656..2951248 + 1593 WP_221063632.1 RNA repair transcriptional activator RtcR -
K5658_RS13410 (MishRS11D_26530) 2951524..2952156 + 633 WP_221066980.1 YecA family protein -
K5658_RS13415 2952247..2952579 - 333 WP_221063633.1 hypothetical protein -
K5658_RS13420 (MishRS11D_26540) 2952856..2953140 - 285 WP_221063634.1 PilZ domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(10-57)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15912.40 Da        Isoelectric Point: 8.0505

>T33058 WP_221063630.1 NZ_AP019783:c2949116-2948688 [Methylomagnum ishizawai]
MPKLYILDTDTCSFVIRNKPPEARQRMNSVPLDQQVISIVTYAELLYGVRRSSSAKVNRGVVENFVRHLGILDWNRAAAE
RYAELRTQLEAAGTPIGAMDMMIAAHALSLDAVVVTNNERHFRRVPGLVVENWLTEIPVPGL

Download         Length: 429 bp

>T33058 NZ_AP019783:c2949116-2948688 [Methylomagnum ishizawai]
ATGCCGAAGCTCTACATCCTCGACACGGATACCTGTTCGTTCGTCATCAGGAACAAGCCGCCCGAAGCCCGGCAGCGCAT
GAACTCGGTGCCTTTGGACCAGCAGGTCATTTCCATCGTGACCTATGCCGAGTTGCTATATGGCGTGCGGCGTTCTTCCA
GCGCCAAGGTCAACCGCGGGGTGGTCGAAAATTTTGTGCGCCACCTGGGCATCCTGGATTGGAACCGCGCCGCCGCCGAG
CGCTATGCCGAGTTGCGGACCCAGTTGGAAGCCGCCGGTACGCCCATCGGGGCCATGGACATGATGATCGCGGCGCACGC
CCTGAGCTTGGACGCGGTGGTCGTGACCAACAACGAGCGGCATTTCCGTAGGGTGCCGGGGTTGGTGGTGGAGAACTGGC
TGACCGAAATACCCGTACCCGGCTTGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9229.37 Da        Isoelectric Point: 4.4463

>AT33058 WP_221063631.1 NZ_AP019783:c2949352-2949116 [Methylomagnum ishizawai]
MYETRVAKLFKNGSSQAVRLPTEFRFEGKEVFIRKEGDKVILSPKPESWDDFFDDPDRVTADFMAEREDLPPQERELF

Download         Length: 237 bp

>AT33058 NZ_AP019783:c2949352-2949116 [Methylomagnum ishizawai]
ATGTATGAAACGCGGGTCGCCAAGCTTTTTAAGAACGGTTCCAGCCAAGCCGTGCGCCTGCCCACCGAATTCCGCTTCGA
GGGCAAGGAAGTGTTCATCCGCAAGGAGGGCGACAAGGTGATCCTGTCGCCCAAACCGGAATCCTGGGACGATTTTTTCG
ATGATCCCGACCGGGTTACGGCGGATTTCATGGCGGAGCGGGAAGACTTGCCGCCCCAGGAGCGGGAGTTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References