Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 252573..252984 Replicon chromosome
Accession NZ_AP019782
Organism Methylogaea oryzae strain E10

Toxin (Protein)


Gene name hicA Uniprot ID A0A8D4VLU3
Locus tag K5607_RS01175 Protein ID WP_054774492.1
Coordinates 252796..252984 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A8D4VK82
Locus tag K5607_RS01170 Protein ID WP_054774491.1
Coordinates 252573..252785 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5607_RS01155 (MoryE10_02260) 249283..250332 + 1050 WP_221047970.1 chemotaxis-specific protein-glutamate methyltransferase CheB -
K5607_RS18160 (MoryE10_02270) 250335..251507 + 1173 WP_221047971.1 fused response regulator/phosphatase -
K5607_RS01165 (MoryE10_02280) 251518..252555 - 1038 WP_221047972.1 lipopolysaccharide heptosyltransferase II -
K5607_RS01170 (MoryE10_02290) 252573..252785 - 213 WP_054774491.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K5607_RS01175 (MoryE10_02300) 252796..252984 - 189 WP_054774492.1 type II toxin-antitoxin system HicA family toxin Toxin
K5607_RS01180 (MoryE10_02310) 253016..253936 - 921 WP_221047973.1 branched-chain amino acid transaminase -
K5607_RS01185 (MoryE10_02320) 253985..256837 - 2853 WP_221047974.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
K5607_RS01190 (MoryE10_02330) 256931..257713 - 783 WP_054774392.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6819.80 Da        Isoelectric Point: 10.4826

>T33053 WP_054774492.1 NZ_AP019782:c252984-252796 [Methylogaea oryzae]
MKVKELIAWIESDGWTQVRQKGSHRQYHHPAKSGTVTVSGKPSVDVPPDTLNSVLKQAGLKP

Download         Length: 189 bp

>T33053 NZ_AP019782:c252984-252796 [Methylogaea oryzae]
ATGAAGGTCAAAGAATTGATTGCCTGGATCGAGTCGGACGGTTGGACACAAGTTCGCCAAAAAGGCAGCCATCGGCAGTA
CCACCATCCGGCCAAGTCGGGAACGGTGACCGTATCGGGCAAGCCCAGTGTCGATGTGCCGCCGGACACACTGAACAGTG
TGTTGAAACAGGCCGGTTTAAAGCCGTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7584.66 Da        Isoelectric Point: 4.2556

>AT33053 WP_054774491.1 NZ_AP019782:c252785-252573 [Methylogaea oryzae]
MRYLVVLEEGPASFGAYVPDLPGCVAAGESREEVLALIREAIEFHIEGLKEEGRMLPQPHSSSAFVEIAA

Download         Length: 213 bp

>AT33053 NZ_AP019782:c252785-252573 [Methylogaea oryzae]
ATGCGCTATCTAGTTGTGCTTGAGGAAGGCCCGGCCAGTTTCGGCGCCTACGTGCCGGACCTGCCTGGCTGCGTCGCCGC
AGGCGAATCGCGGGAGGAAGTATTGGCGCTGATCCGAGAAGCCATCGAATTCCACATCGAAGGCCTCAAAGAAGAGGGCC
GCATGCTGCCTCAGCCTCATTCGTCCAGCGCATTCGTCGAAATCGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References