Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 4229137..4229576 Replicon chromosome
Accession NZ_AP019777
Organism Methylomonas koyamae strain Fw12E-Y

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MKFW12EY_RS19055 Protein ID WP_054762071.1
Coordinates 4229137..4229364 (-) Length 76 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MKFW12EY_RS19060 Protein ID WP_054762073.1
Coordinates 4229367..4229576 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKFW12EY_RS19045 (MKFW12EY_37910) 4225380..4228034 - 2655 WP_054762087.1 carbamoyltransferase HypF -
MKFW12EY_RS19050 (MKFW12EY_37920) 4228034..4229071 - 1038 WP_221053574.1 hydrogenase expression/formation protein HypE -
MKFW12EY_RS19055 (MKFW12EY_37930) 4229137..4229364 - 228 WP_054762071.1 type II toxin-antitoxin system HicA family toxin Toxin
MKFW12EY_RS19060 (MKFW12EY_37940) 4229367..4229576 - 210 WP_054762073.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MKFW12EY_RS19065 (MKFW12EY_37950) 4229895..4231187 - 1293 WP_054762075.1 hypothetical protein -
MKFW12EY_RS19070 (MKFW12EY_37960) 4231524..4231757 + 234 WP_054762089.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MKFW12EY_RS19075 (MKFW12EY_37970) 4231744..4232160 + 417 WP_054762077.1 PIN domain-containing protein -
MKFW12EY_RS19080 (MKFW12EY_37980) 4232248..4232502 + 255 WP_054762078.1 prevent-host-death protein -
MKFW12EY_RS19085 (MKFW12EY_37990) 4232502..4232777 + 276 WP_054762080.1 plasmid stabilization protein -
MKFW12EY_RS19090 (MKFW12EY_38000) 4232944..4233804 - 861 WP_054762081.1 hypothetical protein -
MKFW12EY_RS19095 (MKFW12EY_38010) 4233826..4234461 - 636 WP_054762092.1 YchE family NAAT transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-65)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 76 a.a.        Molecular weight: 8424.91 Da        Isoelectric Point: 10.3070

>T33046 WP_054762071.1 NZ_AP019777:c4229364-4229137 [Methylomonas koyamae]
MGNIPVLKPREVVVLLELLGFTEARQRGSHKQFRHPDGRCTTVPFHAGRDISPILLRQIAKDIGLSIEELLKLQA

Download         Length: 228 bp

>T33046 NZ_AP019777:c4229364-4229137 [Methylomonas koyamae]
ATGGGAAACATACCTGTTCTTAAACCTCGCGAAGTTGTCGTTTTGCTTGAACTATTGGGATTCACCGAGGCTCGGCAACG
AGGTTCGCATAAACAATTTCGCCATCCCGATGGCAGATGTACGACGGTGCCGTTTCATGCAGGGCGTGATATTTCGCCGA
TTTTGCTTCGGCAGATCGCTAAAGATATTGGCTTGAGTATTGAAGAGTTACTTAAGCTGCAAGCCTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7580.62 Da        Isoelectric Point: 4.0852

>AT33046 WP_054762073.1 NZ_AP019777:c4229576-4229367 [Methylomonas koyamae]
MKTYTAIIEKCHDTGLYVGFIPGFAGAHSQAESLDELNKNLREVIEMLLEDGEPILEAEFIGTQNVVVA

Download         Length: 210 bp

>AT33046 NZ_AP019777:c4229576-4229367 [Methylomonas koyamae]
ATGAAAACCTACACAGCAATCATAGAAAAATGCCACGATACCGGATTATACGTAGGCTTCATTCCTGGATTTGCAGGCGC
GCATAGCCAAGCGGAGTCGTTGGATGAACTGAATAAAAATCTTCGGGAAGTGATTGAAATGTTGCTTGAAGATGGCGAGC
CGATACTGGAAGCCGAATTTATCGGCACTCAAAATGTAGTCGTCGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References