Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3257791..3258428 Replicon chromosome
Accession NZ_AP019777
Organism Methylomonas koyamae strain Fw12E-Y

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKFW12EY_RS14575 Protein ID WP_054762536.1
Coordinates 3258021..3258428 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag MKFW12EY_RS14570 Protein ID WP_054762539.1
Coordinates 3257791..3258021 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKFW12EY_RS14550 (MKFW12EY_29090) 3253051..3255867 + 2817 WP_221053262.1 excinuclease ABC subunit UvrA -
MKFW12EY_RS14555 (MKFW12EY_29100) 3255883..3256263 + 381 WP_054762543.1 nucleotidyltransferase domain-containing protein -
MKFW12EY_RS14560 (MKFW12EY_29110) 3256244..3256690 + 447 WP_054762541.1 DUF86 domain-containing protein -
MKFW12EY_RS14565 (MKFW12EY_29120) 3256966..3257556 + 591 WP_054762540.1 Uma2 family endonuclease -
MKFW12EY_RS14570 (MKFW12EY_29130) 3257791..3258021 + 231 WP_054762539.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MKFW12EY_RS14575 (MKFW12EY_29140) 3258021..3258428 + 408 WP_054762536.1 type II toxin-antitoxin system VapC family toxin Toxin
MKFW12EY_RS14580 (MKFW12EY_29150) 3258615..3259031 + 417 WP_054762545.1 hypothetical protein -
MKFW12EY_RS14585 (MKFW12EY_29160) 3259028..3260332 + 1305 WP_054762534.1 P-loop NTPase -
MKFW12EY_RS14590 (MKFW12EY_29170) 3260325..3261737 + 1413 WP_221053263.1 hypothetical protein -
MKFW12EY_RS14595 (MKFW12EY_29180) 3261784..3262167 - 384 WP_157199439.1 YciI family protein -
MKFW12EY_RS14600 (MKFW12EY_29190) 3262223..3262729 - 507 WP_054762530.1 DUF45 domain-containing protein -
MKFW12EY_RS14605 (MKFW12EY_29200) 3262726..3263340 - 615 WP_221053264.1 DUF938 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15342.53 Da        Isoelectric Point: 6.2340

>T33043 WP_054762536.1 NZ_AP019777:3258021-3258428 [Methylomonas koyamae]
MPVRYLLDTNICIYIAKYRPPAVRERFARHSASELAMSVITLGELRFGAEKSQVRDRAITAIDELTGLIPICDLPETAGE
HYGQIRAELQKIGQPIGNNDLWLAAHARSQEWVLVSNNEREFLRVPDLRVENWAS

Download         Length: 408 bp

>T33043 NZ_AP019777:3258021-3258428 [Methylomonas koyamae]
ATGCCAGTACGGTATCTACTGGACACCAACATCTGCATCTACATTGCAAAATATCGCCCTCCCGCCGTGCGCGAGCGCTT
CGCCCGCCACTCGGCCAGCGAACTGGCTATGTCGGTTATTACCCTGGGCGAATTACGCTTCGGCGCCGAAAAAAGCCAGG
TGCGGGACCGAGCTATTACAGCCATTGACGAATTGACCGGCCTGATTCCGATCTGCGACTTGCCCGAAACGGCCGGGGAA
CATTACGGACAAATCCGCGCGGAGCTACAAAAAATTGGCCAACCGATAGGCAATAACGATTTATGGCTGGCCGCCCATGC
TCGGTCTCAAGAGTGGGTATTGGTGTCCAACAATGAACGCGAATTTCTCAGAGTGCCGGATTTGCGGGTTGAGAATTGGG
CGAGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8812.81 Da        Isoelectric Point: 4.6151

>AT33043 WP_054762539.1 NZ_AP019777:3257791-3258021 [Methylomonas koyamae]
MTYARIFQSGNSQAVRLPKEFRFNADRVEIFRRGDEIVLRETPTNATAIFDALSTLREDFMAEGREDSPPQEREAF

Download         Length: 231 bp

>AT33043 NZ_AP019777:3257791-3258021 [Methylomonas koyamae]
ATGACCTACGCCCGTATTTTTCAATCCGGCAACAGCCAGGCCGTGCGCTTACCCAAGGAATTTAGGTTTAACGCCGACCG
TGTGGAGATCTTTCGCCGCGGCGACGAAATCGTGTTACGAGAAACGCCGACCAACGCCACGGCAATATTCGACGCGCTCA
GTACATTGCGGGAAGACTTCATGGCCGAAGGCCGGGAAGACAGCCCGCCGCAAGAACGCGAGGCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References