Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2517746..2519238 Replicon chromosome
Accession NZ_AP019777
Organism Methylomonas koyamae strain Fw12E-Y

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag MKFW12EY_RS11385 Protein ID WP_054760866.1
Coordinates 2517746..2519008 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag MKFW12EY_RS11390 Protein ID WP_221053012.1
Coordinates 2519005..2519238 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKFW12EY_RS11350 (MKFW12EY_22710) 2513739..2514920 + 1182 WP_064021692.1 pyridoxal phosphate-dependent aminotransferase -
MKFW12EY_RS11360 (MKFW12EY_22720) 2515590..2516360 + 771 WP_054760870.1 zinc-dependent peptidase -
MKFW12EY_RS11365 (MKFW12EY_22730) 2516376..2516696 + 321 WP_054760914.1 hypothetical protein -
MKFW12EY_RS11370 (MKFW12EY_22740) 2516705..2516968 + 264 WP_221053009.1 hypothetical protein -
MKFW12EY_RS11375 (MKFW12EY_22750) 2516968..2517177 + 210 WP_221053010.1 DUF3820 family protein -
MKFW12EY_RS11380 (MKFW12EY_22760) 2517212..2517490 + 279 WP_221053011.1 hypothetical protein -
MKFW12EY_RS11385 (MKFW12EY_22770) 2517746..2519008 - 1263 WP_054760866.1 type II toxin-antitoxin system HipA family toxin Toxin
MKFW12EY_RS11390 (MKFW12EY_22780) 2519005..2519238 - 234 WP_221053012.1 helix-turn-helix transcriptional regulator Antitoxin
MKFW12EY_RS11395 (MKFW12EY_22790) 2519442..2519921 - 480 WP_054760863.1 hypothetical protein -
MKFW12EY_RS11400 (MKFW12EY_22800) 2520024..2520710 - 687 WP_245006283.1 copper resistance protein B -
MKFW12EY_RS11405 (MKFW12EY_22810) 2520703..2522415 - 1713 WP_221053013.1 copper resistance system multicopper oxidase -
MKFW12EY_RS11410 (MKFW12EY_22820) 2522405..2522767 - 363 WP_157199302.1 hypothetical protein -
MKFW12EY_RS23190 2522919..2523047 + 129 WP_256360751.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Transcription regulator, HipB-like

(9-64)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 46606.42 Da        Isoelectric Point: 6.6907

>T33042 WP_054760866.1 NZ_AP019777:c2519008-2517746 [Methylomonas koyamae]
MSHLLAVYLFDRRVGDLTLVEGRLQFSYDADWLQRADATPLSCSLPLQVEPFNDQQTRPFFAGLLPEGKLRQLIARQFQI
SRQNDFALLDHIGGECAGAVSLLQPDQTPLVPKTTNEIDWLSDTDVLALLDELPQRPMLAGQDGLRLSLAGAQDKLPVVF
DGQRIGLPRNGTPSSHILKPAIADVEDSVNNEAFCMALARAMQLQTAQSQIGRIGERQFLLVERYDRTLAANGQRLRLHQ
EDFCQALGVVPELKYQNEGGPGLDQCFDLVRRVTRPSAPQVLRLLDAVIFNALIGNHDTHAKNFSILYAEKGSVLAPLYD
VLSTAVYPSLTPKMAMQLGGKYKFSEVQARHWDRFAQAAGLSVAQTRKRILGLCQRLPLVARTLQASADHEFVGNPLVEQ
IVELIEQRAALTARRLTDKA

Download         Length: 1263 bp

>T33042 NZ_AP019777:c2519008-2517746 [Methylomonas koyamae]
ATGAGCCATTTGCTTGCCGTCTATTTATTTGATCGTCGAGTGGGGGATTTGACTCTGGTTGAGGGCAGACTGCAATTTAG
CTATGACGCAGACTGGCTGCAACGAGCCGACGCTACCCCTCTCTCCTGTTCGTTACCGTTGCAAGTTGAGCCGTTCAACG
ACCAACAAACGCGGCCGTTCTTTGCCGGCCTGTTACCGGAAGGCAAATTACGCCAACTGATCGCCCGCCAGTTTCAGATC
TCGAGACAAAATGACTTTGCCTTGCTCGATCATATCGGCGGCGAATGCGCCGGTGCCGTCTCACTGCTACAGCCTGACCA
AACACCGCTTGTACCGAAAACGACGAATGAGATTGACTGGTTATCCGACACTGACGTCCTTGCCTTGCTGGATGAATTAC
CGCAGCGCCCGATGCTGGCAGGTCAGGATGGCTTGCGTCTATCGTTGGCGGGCGCTCAGGATAAGTTGCCAGTGGTGTTT
GATGGTCAACGAATCGGTCTGCCCCGCAATGGCACGCCCAGTAGCCATATTCTCAAACCGGCCATCGCTGACGTCGAAGA
CAGTGTAAACAACGAAGCTTTTTGCATGGCATTGGCCAGAGCAATGCAACTTCAGACCGCACAGTCGCAAATTGGCAGAA
TTGGAGAACGCCAATTTCTGTTGGTTGAGCGTTACGACAGAACACTGGCTGCAAATGGCCAACGCTTGCGGCTGCATCAA
GAAGATTTCTGTCAGGCGCTCGGCGTGGTGCCGGAACTGAAATATCAGAACGAAGGCGGGCCGGGGTTGGACCAGTGCTT
TGACTTGGTCCGCCGCGTGACCCGACCGAGTGCTCCGCAGGTGTTGCGTCTGCTGGATGCAGTGATTTTCAATGCCTTGA
TCGGCAACCACGACACCCATGCCAAGAACTTTTCTATCTTGTATGCAGAGAAGGGTTCCGTTCTGGCGCCGCTCTACGAC
GTATTGTCAACCGCCGTTTATCCCAGTCTGACGCCCAAAATGGCGATGCAGTTGGGCGGCAAATACAAGTTCAGCGAAGT
GCAGGCCCGGCATTGGGATCGTTTTGCTCAAGCGGCGGGCTTGTCGGTAGCGCAAACTCGAAAACGTATCCTTGGTTTAT
GCCAACGGCTACCGCTGGTCGCGCGCACTTTGCAGGCCTCGGCGGATCATGAATTTGTCGGAAATCCGCTGGTTGAACAA
ATCGTAGAACTGATCGAGCAACGCGCGGCGTTGACGGCCAGACGGTTGACCGATAAGGCCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8206.53 Da        Isoelectric Point: 5.6156

>AT33042 WP_221053012.1 NZ_AP019777:c2519238-2519005 [Methylomonas koyamae]
MINIHSTQQLGQALRTARKHLGLTQSELALAAGVGVRFIVDLEAGKPTVRLETVMRVIEALGGEVMLDGLPDTTEAP

Download         Length: 234 bp

>AT33042 NZ_AP019777:c2519238-2519005 [Methylomonas koyamae]
ATGATCAACATTCACTCCACCCAACAACTTGGCCAAGCGCTACGCACCGCTCGCAAACACCTCGGATTAACTCAATCCGA
ATTGGCGTTGGCGGCAGGCGTGGGTGTGCGCTTTATCGTCGATCTCGAAGCCGGCAAGCCGACCGTACGCCTGGAAACGG
TGATGCGCGTGATCGAGGCATTGGGTGGTGAGGTCATGCTTGATGGCCTGCCGGACACCACCGAAGCACCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References