Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1345768..1346239 | Replicon | chromosome |
| Accession | NZ_AP019761 | ||
| Organism | Escherichia coli O111:H- strain 110512 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | EC110512_RS06730 | Protein ID | WP_001303511.1 |
| Coordinates | 1345768..1346046 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | EC110512_RS06735 | Protein ID | WP_001302048.1 |
| Coordinates | 1346048..1346239 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EC110512_RS06695 | 1341075..1341344 | - | 270 | WP_000003742.1 | excisionase | - |
| EC110512_RS06700 | 1341406..1343871 | - | 2466 | WP_000048442.1 | exonuclease | - |
| EC110512_RS06705 | 1343964..1344155 | - | 192 | WP_001090200.1 | DUF1482 family protein | - |
| EC110512_RS06710 | 1344152..1344340 | - | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| EC110512_RS06720 | 1344824..1345042 | - | 219 | WP_001171930.1 | hypothetical protein | - |
| EC110512_RS06725 | 1345083..1345472 | - | 390 | WP_001447517.1 | hypothetical protein | - |
| EC110512_RS06730 | 1345768..1346046 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EC110512_RS06735 | 1346048..1346239 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| EC110512_RS06740 | 1346260..1346631 | - | 372 | WP_001169687.1 | hypothetical protein | - |
| EC110512_RS06745 | 1346729..1347031 | + | 303 | WP_001444689.1 | transcriptional regulator | - |
| EC110512_RS06750 | 1347028..1347453 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| EC110512_RS06755 | 1347476..1348210 | + | 735 | Protein_1284 | helix-turn-helix domain-containing protein | - |
| EC110512_RS06760 | 1348161..1348331 | + | 171 | WP_146868674.1 | type I toxin-antitoxin system Hok family toxin | - |
| EC110512_RS06770 | 1348499..1348771 | + | 273 | WP_012817871.1 | hypothetical protein | - |
| EC110512_RS06775 | 1348773..1349828 | + | 1056 | WP_001369253.1 | DUF968 domain-containing protein | - |
| EC110512_RS06780 | 1349829..1350194 | + | 366 | WP_000140024.1 | RusA family crossover junction endodeoxyribonuclease | - |
| EC110512_RS06785 | 1350203..1350733 | + | 531 | WP_000640048.1 | DUF1133 family protein | - |
| EC110512_RS06790 | 1350975..1351172 | + | 198 | WP_000917750.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | espX7/nleL / espN / espK | 1332819..1392054 | 59235 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T33010 WP_001303511.1 NZ_AP019761:c1346046-1345768 [Escherichia coli O111:H-]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T33010 NZ_AP019761:c1346046-1345768 [Escherichia coli O111:H-]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT33010 WP_001302048.1 NZ_AP019761:c1346239-1346048 [Escherichia coli O111:H-]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT33010 NZ_AP019761:c1346239-1346048 [Escherichia coli O111:H-]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|