Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1251215..1252010 Replicon chromosome
Accession NZ_AP019761
Organism Escherichia coli O111:H- strain 110512

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag EC110512_RS06215 Protein ID WP_000854914.1
Coordinates 1251636..1252010 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag EC110512_RS06210 Protein ID WP_001280954.1
Coordinates 1251215..1251589 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC110512_RS06170 1246240..1246878 + 639 WP_000502842.1 ParB N-terminal domain-containing protein -
EC110512_RS06180 1248222..1248542 + 321 WP_000149392.1 phospholipase -
EC110512_RS06190 1248882..1249700 + 819 WP_001234682.1 DUF945 domain-containing protein -
EC110512_RS06195 1249791..1250276 + 486 WP_000214398.1 antirestriction protein -
EC110512_RS06200 1250292..1250768 + 477 WP_001345397.1 RadC family protein -
EC110512_RS06205 1250831..1251052 + 222 WP_001220314.1 DUF987 domain-containing protein -
EC110512_RS06210 1251215..1251589 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EC110512_RS06215 1251636..1252010 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
EC110512_RS06220 1252007..1252498 + 492 WP_000976857.1 hypothetical protein -
EC110512_RS06225 1252510..1252707 + 198 WP_000839282.1 DUF957 domain-containing protein -
EC110512_RS06230 1252792..1253634 + 843 WP_001280481.1 DUF4942 domain-containing protein -
EC110512_RS06240 1254105..1255043 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
EC110512_RS06245 1255098..1255835 + 738 WP_000283664.1 zinc-binding phosphatase -
EC110512_RS06250 1255859..1256413 + 555 WP_001001902.1 molecular chaperone YcdY -
EC110512_RS06255 1256515..1257006 + 492 WP_001297187.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T33009 WP_000854914.1 NZ_AP019761:1251636-1252010 [Escherichia coli O111:H-]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T33009 NZ_AP019761:1251636-1252010 [Escherichia coli O111:H-]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT33009 WP_001280954.1 NZ_AP019761:1251215-1251589 [Escherichia coli O111:H-]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT33009 NZ_AP019761:1251215-1251589 [Escherichia coli O111:H-]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References